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The safety and warning information provided here is crucial for the proper use of this medication. Please read carefully and discuss any questions or concerns with your healthcare provider.

• Risk of Overdose and Misuse: Mucinex DM (guaifenesin / dextromethorphan) contains ingredients commonly found in other over-the-counter medications. Using multiple products with these ingredients can result in accidental overdose, which is hazardous. Misuse of dextromethorphan, particularly at high doses, can lead to poisoning. Note that many stores require purchasers to be over 18 for products containing dextromethorphan. Exercise caution when combining with other similar medications.

• Drug Interactions: If you are taking or have recently taken medications for Parkinson’s disease or depression, specifically monoamine oxidase inhibitors (MAOIs), consult your healthcare provider before using Mucinex DM. Interaction with these medications can cause serious conditions such as dangerously high blood pressure and serotonin syndrome. It is recommended to seek alternative cough remedies if you've used MAOIs in the past two weeks.

• Phenylketonuria (PKU) Caution – Dissolvable Granules: The dissolvable granules of Mucinex DM contain phenylalanine, a sweetener safe for most but harmful for individuals with PKU, a genetic condition. If you or your child has PKU, avoid the dissolvable granules and consider the oral solution or tablet forms, which do not contain phenylalanine. Consult with a healthcare provider to ensure you're choosing a safe product.

• Contraindications: Do not use this medication if you are currently taking or have taken a monoamine oxidase inhibitor (MAOI) within the last 14 days, as it poses significant health risks.

Ensure you follow these guidelines to safely use Mucinex DM and consult your healthcare provider if you have any doubts or require further clarification.

When using this medication, some individuals may experience mild side effects such as dizziness, drowsiness, nausea, diarrhea, and headaches. These are generally not severe and tend to resolve on their own. However, if they persist or worsen, it is advisable to contact your healthcare provider for guidance.

There are also rare but serious side effects that may occur, requiring immediate medical attention. These include severe allergic reactions characterized by rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, and trouble breathing. Additionally, symptoms such as vomiting, belly discomfort, constipation, racing heart, and difficulty breathing are considered serious.

If you experience any of these severe side effects, seek urgent medical care. Always pay attention to how you feel and reach out to a healthcare professional if you have any concerns about the effects you are experiencing. Remember, while these side effects are possible, many people using this medication do not experience serious adverse effects.

When using this medication, it's crucial to avoid certain MAO inhibitors as they can lead to a severe and potentially fatal interaction. Do not take isocarboxazid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, or tranylcypromine while on this medication. Additionally, most MAO inhibitors should be avoided for at least two weeks prior to starting this medication. Consult your doctor for guidance on when to begin or discontinue use. Another drug that may interact with this medication is rolapitant.

It's important to be aware that guaifenesin and dextromethorphan are present in both prescription and over-the-counter products. Carefully check all medication labels to ensure you are not consuming multiple products containing guaifenesin or dextromethorphan. Guaifenesin could also affect certain laboratory tests, such as urine tests for specific acids, potentially leading to inaccurate results. Inform lab personnel and all healthcare providers that you are using this medication.