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This document outlines essential safety information on the use of HCG, focusing on potential risks, precautions, and necessary actions in case of emergencies. It is crucial to understand these warnings and discuss any concerns with your healthcare provider.

• Severe Allergic Reactions: HCG may cause serious allergic reactions, including anaphylaxis, characterized by difficulty breathing, swelling of the lips or tongue, or a rash. Immediate medical attention is required if these symptoms occur.

• Ovarian Hyperstimulation Syndrome (OHSS): In females, HCG can lead to OHSS, where ovaries become excessively enlarged. Symptoms include stomach pain, bloating, and weight gain. Severe cases can cause intense pain, breathing difficulties, nausea, vomiting, or diarrhea. These symptoms might appear within days or up to 10 days post-injection, often resolving within two weeks. Notify your healthcare provider immediately if severe symptoms occur.

• Blood Clots: The use of HCG increases the risk of developing blood clots, potentially resulting in serious conditions like heart attacks, strokes, or pulmonary embolisms. The risk is heightened by smoking, OHSS, or a history of blood clots. Seek emergency medical help if you experience pain in limbs, chest pain, sudden headaches, breathing problems, or sudden speech or vision changes.

• Multiple Pregnancies: HCG can raise the likelihood of conceiving multiple babies (e.g., twins or triplets). Discuss this potential with your partner and healthcare provider before starting treatment.

• Early Puberty in Males: For males treated for cryptorchidism, HCG may trigger early puberty. Signs include voice changes and hair growth under arms or near genitals. Discontinue use and consult your child's provider if these signs appear.

• Cancer Risk in Males: There have been reports of testicular tumors in young men using HCG for infertility due to hypogonadism. Contact your provider promptly if you detect lumps or swelling in the testicles, abdominal, groin, scrotal pain, or back pain.

• Water Retention: HCG may cause water retention, which can exacerbate conditions like asthma, kidney or heart issues, seizures, and migraines. Discuss your medical history with your provider before commencing HCG.

Contraindications: HCG should not be used if any of the following conditions apply, as it could lead to serious health issues:

• Early puberty
• Prostate cancer (or other androgen-dependent cancers)
• Current pregnancy

Always consult with your healthcare provider to determine if HCG is safe for you, considering your medical history and current health status.

Common side effects:

• Headache
• Irritability
• Restlessness
• Tiredness
• Pain at the injection site

Less common but important to monitor:

• Mood changes like depression
• Swelling (edema)
• Early puberty signs in boys
• Breast growth in males
• Skin redness
• Itchiness
• Rash

Serious side effects:

• Serious allergic reactions
• Ovarian hyperstimulation syndrome (OHSS)
• Blood clots
• Swollen or ruptured ovarian cysts

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• gonadorelin