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This medication comes with important safety information regarding potential risks and precautions. Please review the following points carefully and discuss any concerns with your healthcare provider:

• Swollen Ovaries: Menopur (menotropins) may cause ovarian enlargement, leading to stomach bloating or pain. These symptoms typically subside within 2 to 3 weeks. To minimize this risk, your fertility specialist will prescribe the lowest effective dose. Notify your healthcare team immediately if you experience stomach pain after injection. High doses increase this risk.

• Ovarian Hyperstimulation Syndrome (OHSS): Menopur (menotropins) can occasionally result in OHSS, a condition where the ovaries become overly enlarged post-injection. This painful condition may cause vomiting, diarrhea, and potentially severe complications like breathing difficulties and ovarian damage. The risk is heightened if currently pregnant.

• Lung Problems and Blood Clots: There have been instances of life-threatening lung issues and blood clots in some individuals using gonadotropins like Menopur (menotropins). Blood clots can lead to critical complications, such as heart attacks, strokes, or pulmonary embolism. Risks increase with a personal or family history of blood clots, smoking, OHSS, or being overweight.

• Ovarian Twisting: Treatment with Menopur (menotropins) has been associated with ovarian twisting, where the ovary twists on its supporting tissues, potentially cutting off blood flow. This can cause sudden severe pain, nausea, and vomiting. Risks are higher for those with a history of ovarian cysts, previous stomach surgery, or PCOS. Inform your fertility specialist of any relevant medical history before starting treatment.

• Multiple Pregnancies: Gonadotropin treatments like Menopur (menotropins) significantly increase the likelihood of conceiving multiple babies (e.g., twins, triplets). Discuss the implications of a multiple pregnancy with your partner prior to starting treatment.

• Pregnancy Complications: Assisted reproductive technologies, such as IVF, may elevate risks of complications during pregnancy, including birth defects, ectopic pregnancies, and miscarriages. The exact reasons for these risks remain unclear. Close monitoring by your fertility specialist is advised. Discuss any concerns with your care team.

Contraindications: Do not use this medication if any of the following conditions apply, as serious health risks may arise:

• Elevated FSH levels indicating possible ovarian dysfunction
• Current pregnancy
• Uncontrolled endocrine disorders not related to sex hormones
• Presence of sex hormone-dependent tumors
• Tumors in the pituitary gland or hypothalamus
• Unexplained abnormal vaginal bleeding
• Unexplained ovarian cysts or enlargement

Please consult your healthcare provider if you have any of these conditions before starting Menopur (menotropins).

When using this medication, it's important to be aware of potential side effects, which can range from mild to serious. Common side effects include headache, mild stomach pain or bloating, breast tenderness, dizziness, and redness or pain at the injection site. These effects are generally not severe and often resolve on their own. However, if they persist or worsen, consulting a healthcare provider is advised.

More serious side effects, although rare, require immediate medical attention. These include flu-like symptoms such as fever, chills, joint pain, muscle ache, and tiredness. Additionally, if you experience weakness on one side of the body, difficulty speaking, sudden vision changes, severe headache, pain or swelling in the calf muscles, chest pain, or shortness of breath, seek urgent care.

This medication may lead to ovarian hyperstimulation syndrome (OHSS), which can be serious if fluid accumulates in the stomach, chest, and heart area. Symptoms of severe OHSS include severe abdominal pain, nausea, vomiting, rapid weight gain, and decreased urination. An allergic reaction is also possible, with symptoms like rash, itching, and difficulty breathing, requiring immediate medical help.

Rare side effects such as lung problems, heart attack, stroke, and ectopic pregnancy are critical and necessitate prompt medical intervention. If you notice symptoms like trouble breathing, chest pain, or severe pelvic pain, contact emergency services. Always keep your healthcare provider informed of any unusual symptoms you experience.