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This medication's safety and warning details are crucial for understanding its potential risks. Please consider the following information carefully and consult your healthcare provider if you have any questions or concerns.

• Altered Stress Hormone Levels: There is a risk of excessive absorption of clocortolone (Cloderm) through the skin under certain conditions, which may lead to altered stress hormone levels. The risk is heightened when:
  • The medication is applied to large body areas.
  • It is used for extended periods.
  • More than one topical steroid is applied.
  • The treated area is covered with tight bandages.
  • It is applied to damaged skin.
  • It is used in young children. There are no specific contraindications provided for this medication. Always follow your healthcare provider's guidance and report any unusual symptoms or concerns after using this medication.

Common side effects:

• Stinging
• Burning
• Itching
• Irritation
• Dryness
• Redness at the application site

Less common but important to monitor:

• Skin thinning
• Discoloration
• Acne
• Unwanted hair growth
• Folliculitis
• Worsening skin infections

Serious side effects:

• Absorption into the bloodstream
• Unusual tiredness
• Weight loss
• Headaches
• Swelling of the ankles or feet
• Increased thirst or urination
• Vision problems
• Serious allergic reactions
• Rash
• Itching or swelling of the face, tongue, or throat
• Severe dizziness
• Difficulty breathing

Clocortolone is a topical corticosteroid used to treat various skin conditions. While it is applied to the skin, some of the medication can be absorbed into the bloodstream, potentially leading to interactions with other medications.

Interactions with Diabetes Medications:

When clocortolone is absorbed systemically, it may interfere with blood sugar control, potentially reducing the effectiveness of diabetes medications such as tirzepatide (Mounjaro) and linagliptin. This effect is more likely if clocortolone is applied over large areas, used for extended periods, or applied to broken or inflamed skin. In such cases, it's important to monitor blood sugar levels closely and consult a healthcare provider for possible adjustments to diabetes medication dosages.

Interactions with Other Medications:

Clocortolone may also interact with other drugs:

• Benzthiazide: Combining clocortolone with benzthiazide can increase the risk and severity of electrolyte imbalances.

• Digoxin: Using clocortolone alongside digoxin may heighten the risk and severity of adverse effects.

• Disopyramide: Concurrent use with clocortolone can raise the likelihood and severity of hyperglycemia.

• Voriconazole: Combining these medications may lead to increased serum concentrations of voriconazole.

General Precautions:

To minimize potential interactions, inform your healthcare provider about all medications, supplements, and over-the-counter products you are currently using. Avoid exceeding the recommended dose or duration of clocortolone use, and do not use it under occlusive dressings unless directed by a healthcare professional. If you experience unusual symptoms or side effects, contact your healthcare provider promptly.