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It is crucial to be aware of the safety information and warnings related to the use of this medication. Please carefully go through the following points and consult your healthcare provider if you have any concerns.

• Lowered Stress Hormone Levels: Abruptly reducing or discontinuing dexamethasone after long-term use can lead to adrenal insufficiency, where your body is unable to properly respond to stress. Symptoms may include joint or muscle pain, severe fatigue, and depression. Any dosage changes should be made gradually under your doctor's guidance, especially in situations of stress such as trauma, surgery, or infection.

• Increased Risk of Infections: Long-term use of dexamethasone can elevate your risk of infections and may mask infection symptoms. Avoid contact with individuals who have chickenpox or measles. If you have a history of tuberculosis (TB), your doctor will need to monitor you closely and may prescribe TB medications to prevent or treat potential reactivation.

• High Blood Pressure and Kidney Issues: Dexamethasone may elevate blood pressure and cause fluid retention, impacting kidney function and potassium levels. Consult your doctor if you have pre-existing conditions like heart failure, high blood pressure, or kidney problems, as dexamethasone may exacerbate these issues.

• Gastrointestinal Problems: The medication can increase the risk of stomach and intestinal lining damage. Avoid alcohol to reduce the risk of stomach irritation. Seek immediate medical attention if you experience stomach pain or bloody/dark stools. Those with a history of stomach ulcers, ulcerative colitis, or who are taking other ulcer-causing medications should exercise caution.

• Bone Weakness: Prolonged use of dexamethasone can lead to weakened bones, potentially causing osteoporosis in adults and slowed growth in children. Your doctor may advise increasing calcium and vitamin D intake and engaging in bone-strengthening exercises.

• Eye Issues: Extended use of dexamethasone may increase the risk of cataracts, glaucoma, and certain eye infections. Avoid using this medication if you have herpes simplex of the eye. Report any changes in vision, eye pain, or blurred vision to your doctor immediately.

Contraindications: Do not use this medication if you have a systemic fungal infection, as it may pose severe health risks. Always consult your healthcare provider if you have concerns regarding these conditions.

When taking this medication, you may experience some common side effects such as stomach upset, headache, difficulty sleeping, and nausea. These are generally mild and often temporary. Should they persist or worsen, it's advisable to consult your healthcare provider. In some cases, you might also notice changes like increased hunger, weight gain, or mood swings, which are usually manageable.

Other side effects can include skin-related issues like acne, dry or thinning skin, or thinning scalp hair. Some individuals report abnormal fat deposits and swelling in the feet and ankles due to fluid retention. Additionally, you may experience vision changes, slower wound healing, or muscle weakness. While these effects are not common, it's important to discuss them with your healthcare provider if they arise.

It is crucial to be aware of more serious side effects, which are rare but require immediate medical attention. These include signs of infection, unusual bruising or bleeding, severe mood changes, or significant vision problems. Blood sugar levels may rise, increasing the risk of diabetes or worsening existing diabetes, so monitoring is essential. Moreover, there is a potential for serious blood clot issues, which could lead to heart attacks or strokes. Be vigilant for symptoms like chest pain, sudden dizziness, or trouble speaking, and seek urgent medical care if they occur.

Lastly, though uncommon, severe allergic reactions can occur, including difficulty breathing, swelling of the face or throat, and severe dizziness. Immediate medical intervention is necessary if these symptoms develop. Always communicate any concerning side effects to your healthcare provider to ensure appropriate management and care.

When taking Dexamethasone, it is important to be aware of potential interactions with other medications. Some drugs, such as Desmopressin, artemether, Praziquantel, rilpivirine, and live rotavirus vaccine, should generally not be used with dexamethasone. Your doctor may choose alternative treatments or adjust your current medications to avoid harmful interactions.

Additionally, there are medications that are usually not recommended to be used with dexamethasone unless necessary. In such cases, your doctor might alter the dosage or frequency of either medication. These include drugs like abametapir, aceclofenac, Celecoxib, bupropion, Carbamazepine, Clarithromycin, and others.

Furthermore, using dexamethasone with certain medications, such as Aspirin, Warfarin, and licorice, may increase the risk of side effects. If these combinations are deemed necessary, your healthcare provider may adjust doses accordingly.

Dexamethasone can also accelerate the removal of other drugs from your system, potentially reducing their effectiveness. This is particularly relevant for medications such as praziquantel and rilpivirine. Always inform your doctor and pharmacist about all medications and supplements you are taking to ensure safe and effective treatment.