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Voriconazole can interact with several medications, and certain drugs should be avoided or used with caution. These include:1. Rifampin and Rifabutin - These can significantly reduce voriconazole levels.2. Carbamazepine and Phenobarbital - These can also decrease voriconazole effectiveness.3. Efavirenz - High doses can affect voriconazole levels.4. Ergot alkaloids - Such as ergotamine, should be avoided due to increased risk of ergotism.5. Sirolimus - Voriconazole can increase sirolimus levels, leading to toxicity.6. St. John's Wort - This herbal supplement can reduce voriconazole levels.Patients should always consult with their healthcare provider before starting or stopping any medication while on voriconazole.

Voriconazole is an antifungal medication used to treat serious fungal infections, including invasive aspergillosis and infections caused by Candida species. It is often prescribed for patients with weakened immune systems or those who have not responded to other antifungal treatments.

Voriconazole, an antifungal medication, has several potential disadvantages and side effects. These may include:1. Visual Disturbances: Patients may experience changes in vision, such as blurred vision, color vision changes, or increased sensitivity to light.2. Liver Toxicity: There is a risk of liver damage, which may manifest as elevated liver enzymes or more severe liver dysfunction.3. Skin Reactions: Some individuals may develop skin rashes or photosensitivity, increasing the risk of sunburn.4. Neurological Effects: Possible side effects include headache, dizziness, and hallucinations.5. Drug Interactions: Voriconazole can interact with a variety of other medications, potentially altering their effects.6. QT Prolongation: It may cause changes in heart rhythm, specifically prolonging the QT interval, which can be serious.7. Renal Impairment: There is a potential risk of kidney function impairment.Patients should be monitored for these side effects, and any concerns should be discussed with a healthcare provider.

The decision to stop taking voriconazole should be made by a healthcare provider. It is important to follow the prescribed course of treatment and not to discontinue the medication without consulting a doctor, as stopping it prematurely may lead to a recurrence of the infection. If there are concerns about side effects or the effectiveness of the medication, it is advisable to discuss these with a healthcare professional.

Voriconazole is the drug of choice for the treatment of invasive aspergillosis, a serious fungal infection. It is also used for certain other serious fungal infections, particularly those caused by Candida species, when other treatments are not effective or appropriate.