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Voriconazole

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Voriconazole is used to treat a variety of fungal infections. It belongs to a class of drugs known as azole antifungals. It works by stopping the growth of fungi.
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200MG, Voriconazole (30 Tablets)

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Voriconazole Side Effects

Nausea/vomiting and headache may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: vision changes (such as blurred vision, color vision changes), sensitivity of eyes to light (photophobia), eye pain, signs of kidney problems (such as change in the amount of urine), bone/joint pain, mental/mood changes (such as hallucinations), swelling hands/ankles/feet, easy bruising/bleeding, unusual skin changes, signs of your adrenal glands not working well (such as loss of appetite, unusual tiredness, weight loss). Get medical help right away if you have any very serious side effects, including: fast/irregular heartbeat, severe dizziness, fainting. Voriconazole has rarely caused very serious (possibly fatal) liver disease. Tell your doctor right away if you develop symptoms of liver disease, such as: nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine. Voriconazole can commonly cause a mild rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction. Get medical help right away if you develop any rash. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever that doesn't go away, new or worsening lymph node swelling, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Interactions

Voriconazole can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include eletriptan, ergot alkaloids (such as dihydroergotamine, ergotamine), certain drugs to treat irregular heartbeat (such disopyramide, dronedarone, quinidine), ivabradine, lurasidone, naloxegol, pimozide, ranolazine, sirolimus, certain "statin" cholesterol drugs (such as lovastatin, simvastatin), tolvaptan, among others. Other medications can affect the removal of voriconazole from your body, which may affect how voriconazole works. Examples include butalbital, efavirenz, mitotane, rifamycins (such as rifabutin, rifampin), ritonavir, secobarbital, certain drugs used to treat seizures (such as carbamazepine, phenobarbital), St. John's wort, among others. Many drugs besides voriconazole may affect the heart rhythm (QT prolongation), including pacritinib, among others.
Voriconazole FAQs
What is the drug voriconazole used for?

Voriconazole is an antifungal medication used to treat serious fungal infections, including invasive aspergillosis and infections caused by Candida species. It is often prescribed for patients with weakened immune systems or those who have not responded to other antifungal treatments.

Voriconazole, an antifungal medication, has several potential disadvantages and side effects. These may include:1. Visual Disturbances: Patients may experience changes in vision, such as blurred vision, color vision changes, or increased sensitivity to light.2. Liver Toxicity: There is a risk of liver damage, which may manifest as elevated liver enzymes or more severe liver dysfunction.3. Skin Reactions: Some individuals may develop skin rashes or photosensitivity, increasing the risk of sunburn.4. Neurological Effects: Possible side effects include headache, dizziness, and hallucinations.5. Drug Interactions: Voriconazole can interact with a variety of other medications, potentially altering their effects.6. QT Prolongation: It may cause changes in heart rhythm, specifically prolonging the QT interval, which can be serious.7. Renal Impairment: There is a potential risk of kidney function impairment.Patients should be monitored for these side effects, and any concerns should be discussed with a healthcare provider.

Voriconazole can interact with several medications, and certain drugs should be avoided or used with caution. These include:1. Rifampin and Rifabutin - These can significantly reduce voriconazole levels.2. Carbamazepine and Phenobarbital - These can also decrease voriconazole effectiveness.3. Efavirenz - High doses can affect voriconazole levels.4. Ergot alkaloids - Such as ergotamine, should be avoided due to increased risk of ergotism.5. Sirolimus - Voriconazole can increase sirolimus levels, leading to toxicity.6. St. John's Wort - This herbal supplement can reduce voriconazole levels.Patients should always consult with their healthcare provider before starting or stopping any medication while on voriconazole.

Voriconazole is the drug of choice for the treatment of invasive aspergillosis, a serious fungal infection. It is also used for certain other serious fungal infections, particularly those caused by Candida species, when other treatments are not effective or appropriate.

The decision to stop taking voriconazole should be made by a healthcare provider. It is important to follow the prescribed course of treatment and not to discontinue the medication without consulting a doctor, as stopping it prematurely may lead to a recurrence of the infection. If there are concerns about side effects or the effectiveness of the medication, it is advisable to discuss these with a healthcare professional.

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