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When using estrogen-containing medications, such as estradiol valerate (Delestrogen), it is essential to be aware of the potential risks and necessary precautions. Here is a summary of critical safety information and warnings to consider:

• Cancer Risks: Estrogens can increase the risk of uterine, breast, and ovarian cancers. If you have a healthy uterus, your healthcare provider may prescribe a progestin to mitigate the risk of uterine cancer. Report any unusual vaginal bleeding to your doctor immediately. Avoid estrogen therapy if you have a history of or current breast cancer.

• Cardiovascular Risks: This medication may raise the risk of serious blood clots, heart attacks, and strokes. Inform your healthcare provider about any personal or family history of blood clots, high blood pressure, diabetes, or smoking habits. Seek immediate medical attention if you experience pain in your limbs, chest pain, severe headaches, breathing difficulties, or sudden changes in speech or vision.

• Dementia: Women aged 65 or older using estrogen or estrogen/progestin therapies may face an increased risk of developing dementia. Estrogen should not be used to prevent dementia. Consult your healthcare provider if you have concerns about memory loss or confusion.

• Gallbladder Issues: Estradiol valerate may lead to gallbladder problems, potentially requiring surgical intervention. Contact your doctor if you experience persistent stomach pain, nausea, vomiting, fever, or jaundice.

• Liver Function: Poor liver function can heighten the side effects of this medication. Do not use if you have a history of liver problems. Discuss your liver health with your healthcare provider before starting treatment.

• Triglycerides and Pancreatitis: Estrogens can increase blood triglyceride levels, potentially leading to heart problems or pancreatitis. Your doctor may monitor your blood lipid levels during treatment.

• Vision Problems: Rarely, users may experience vision issues due to clots. Discontinue use and inform your healthcare provider if you encounter vision changes or migraines.

• Calcium Levels: Estrogen can alter blood calcium levels, especially in women with bone-spreading breast cancer. Watch for symptoms like fatigue, muscle weakness, nausea, or constipation.

• Thyroid Function: This medication may impact thyroid hormone levels, necessitating dosage adjustments for thyroid replacement therapy. Regular blood tests may be required to monitor thyroid function.

• Fluid Retention: Estradiol valerate can cause edema, which could exacerbate heart or kidney conditions. Report any unusual swelling or rapid weight gain to your doctor.

• Other Conditions: Estrogens may worsen conditions such as high blood pressure, hereditary angioedema, asthma, diabetes, migraines, and seizures. Discuss your complete medical history with your healthcare provider prior to use.

In case of an overdose or if you have any questions or concerns, contact your healthcare provider immediately. This medication should not be used by those with certain contraindications, including abnormal vaginal bleeding, high risk of blood clots, or current pregnancy. Always follow your healthcare provider's guidance and have regular check-ups to evaluate the need for ongoing treatment.

When taking this medication, you may experience some common side effects such as nausea, vomiting, bloating, breast tenderness or growth, headaches, weight changes, stomach cramps, and vaginal spotting or breakthrough bleeding. These symptoms are often mild and temporary, but if they persist or worsen, consult your healthcare provider for advice.

Other side effects that have been reported include dizziness, high blood pressure, melasma (dark patches on the skin), trouble tolerating contact lenses, menstrual cramps, nipple discharge, bloating, and mood changes. While these are less common, it is important to monitor your condition and seek advice if they become bothersome.

There are also rare but serious side effects associated with this medication that require immediate medical attention. These include symptoms of heart attack, such as chest pain, sweating, or dizziness, and signs of a stroke, like sudden numbness or weakness, confusion, or difficulty speaking. Additionally, watch for indications of deep vein thrombosis, such as leg cramp or swelling, and pulmonary embolism, which may present as chest pain or trouble breathing. Liver or gallbladder issues might manifest as yellowing of the skin or eyes, dark urine, or stomach pain.

In very rare cases, an allergic reaction may occur, with symptoms including rash, itching, swelling, severe dizziness, or trouble breathing. If you experience any of these symptoms, seek medical help immediately. Always stay informed about potential side effects and communicate with your healthcare provider to ensure your safety while using this medication.