OsteoporosisEstradiol Valerate coupons
Estradiol Valerate

Estradiol Valerate Coupons & Savings Card – Discount Prices from $40.12

Generic for: Delestrogen

Estradiol valerate (Delestrogen) injection is a form of hormone replacement therapy (HRT) used primarily to alleviate symptoms of menopause, such as hot flashes and vaginal dryness. This medication is administered as an injection into the muscle every 1-4 weeks, based on your specific medical needs. It works by supplementing estrogen levels in your body, which can help relieve menopausal symptoms and is also beneficial for individuals with conditions like hypogonadism or primary ovarian insufficiency (POI) where estrogen production is insufficient. Additionally, estradiol valerate is used in palliative care for advanced androgen-dependent prostate cancer in men. Common side effects may include vaginal spotting, breast tenderness, and headaches. Before starting this medication, it's important to consult with a healthcare professional to ensure it's suitable for your condition and to discuss any potential risks.
Our coupons are free to use. Before paying, show the pharmacist your Estradiol Valerate savings card to get your free discount. Use our filters below to edit the prescription box to match your needs. The Estradiol Valerate prices will update based on your prescription needs. Above our Estradiol Valerate coupons, you can change your location to see pharmacy prices and costs in other areas. We're here to help you buy Estradiol Valerate at the lowest price with our prescription discount card.

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5ML of 10MG/ML, Estradiol Valerate (1 Vial)

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CVS

$101.18

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Walgreens

$40.12

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Rite Aid

$87.16

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Albertsons

$94.20

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Walmart

$114.47

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Estradiol Valerate savings card

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Walgreens

$40.12

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Estradiol Valerate dosage forms

The average cost for 1 Vial of Estradiol Valerate (generic Delestrogen) at 5ML of 10MG/ML is $114.94 with a free coupon. This is 78% off the average retail price of $395.48
DosageQuantityPrice fromPer unit
5ML of 10MG/ML1 Vial$87.16$87.16
5ML of 20MG/ML1 Vial$106.1$106.1
5ML of 40MG/ML1 Vial$163.15$163.15

Estradiol Valerate Warnings

The use of estrogen-containing medications, whether alone or combined with progestin, carries certain risks and necessitates careful consideration. Below are essential safety warnings and precautions for individuals considering or currently using such treatments. It is important to discuss these aspects with your healthcare provider to ensure safe and effective use.

  • Cancer Risks: Estrogen therapies can increase the risk of uterine (endometrial) and breast cancer. For those with a healthy uterus, combining estrogen with progestin can help mitigate the risk of endometrial cancer. Regular monitoring and reporting of unusual vaginal bleeding or changes in breast appearance are crucial. Avoid estrogen therapies if you currently have or have had breast cancer.

  • Cardiovascular Concerns: There is an elevated risk of developing blood clots, heart attacks, and strokes with estrogen use. This risk is heightened in individuals who smoke or have a history of cardiovascular issues. Immediate medical attention is required if you experience symptoms such as chest pain, severe headaches, or sudden vision changes.

  • Dementia: Estrogen therapy may increase the risk of dementia, particularly in women over 65. Estrogen and progestin should not be used as a preventive measure against dementia.

  • Gallbladder and Liver Issues: Estrogen use can lead to gallbladder problems and aggravate liver conditions. If you experience symptoms like persistent stomach pain or jaundice, contact your healthcare provider immediately. Those with a history of liver problems should avoid this medication.

  • Metabolic Effects: Estrogens can elevate triglyceride levels, potentially leading to heart issues or pancreatitis. Regular blood tests may be necessary to monitor these levels.

  • Thyroid and Calcium Levels: Estrogen can influence thyroid hormone and calcium levels in the blood. If you have thyroid issues or breast cancer that has spread to bones, consult your provider about potential risks.

  • Fluid Retention and Other Conditions: Estrogen might cause fluid retention, potentially exacerbating heart or kidney problems. It may also worsen conditions such as high blood pressure, asthma, diabetes, migraines, and seizures. Discuss your full medical history with your healthcare provider before starting treatment.

  • Contraindications: Do not use estrogen therapy if you have unexplained vaginal bleeding, a history of estrogen-dependent cancers, blood clots, or if you are currently pregnant.

In case of an overdose, seek emergency medical attention immediately. Regular consultations with your healthcare provider are advised to evaluate the need for continued use of hormone therapy. Always use the lowest effective dose for the shortest duration necessary.

Estradiol Valerate Side Effects

Common side effects:

  • nausea
  • vomiting
  • headache
  • breast tenderness or growth
  • bloating
  • weight changes
  • stomach cramps
  • vaginal spotting or breakthrough bleeding
  • dizziness
  • high blood pressure
  • melasma (dark patches on the skin)
  • menstrual cramps
  • mood changes
  • trouble tolerating contact lenses

    Less common but important to monitor:

  • persistent unusual vaginal bleeding
  • increased thirst or urination
  • mental/mood changes
  • breast lumps

    Serious side effects:

  • serious allergic reactions (rash, itching, swelling, severe dizziness, breathing difficulties)
  • heart attack
  • stroke
  • deep vein thrombosis
  • pulmonary embolism
  • chest pain
  • sudden severe headaches
  • confusion
  • trouble speaking
  • pain/swelling in the legs
  • liver or gallbladder issues (yellowing of the skin or eyes, dark urine, severe abdominal pain)

Estradiol Valerate Interactions

Some medications that can interact with this drug are aromatase inhibitors like Anastrozole, Exemestane, and Letrozole, as well as fezolinetant, Fulvestrant, ospemifene, Raloxifene, Tamoxifen, Toremifene, and Tranexamic Acid. Additionally, this medication might affect the results of certain laboratory tests, such as the metyrapone test, potentially leading to inaccurate results. It's important to inform both your healthcare providers and lab personnel that you are taking this medication.
Estradiol Valerate FAQs
What is estradiol valerate used for?

Estradiol valerate is used primarily for hormone replacement therapy in postmenopausal women to manage symptoms such as hot flashes and vaginal dryness. It is also used in the treatment of hypoestrogenism due to hypogonadism, castration, or primary ovarian failure. Additionally, it can be part of hormone therapy for transgender women and is sometimes used in the management of certain types of prostate cancer.

Estradiol valerate may be prescribed to a man for several reasons, including hormone therapy for transgender women as part of gender-affirming treatment, to manage symptoms of hormone-sensitive cancers such as prostate cancer, or to address hormonal imbalances. It is important for individuals to follow their healthcare provider's guidance when using this medication.

If a male takes estradiol, it can lead to several physiological changes due to its effects as a form of estrogen. These changes may include the development of breast tissue (gynecomastia), decreased libido, reduced testicular size, and potential infertility due to decreased sperm production. Additionally, estradiol can cause changes in fat distribution, leading to a more typically female pattern, and may also affect mood and energy levels. It is important for individuals to consult with a healthcare provider before taking estradiol, as it can have significant effects on the body.

Estradiol and estradiol valerate are both forms of estrogen used in hormone therapy, but they differ in their chemical structure and administration. Estradiol is the natural form of estrogen, while estradiol valerate is a prodrug, meaning it is converted into estradiol in the body. Estradiol valerate is often used in injectable form, allowing for a longer duration of action compared to oral estradiol. This difference in formulation can affect the choice of treatment based on the patient's needs and the desired method of administration.

Estradiol valerate is sometimes used in men as part of hormone therapy for transgender women, to help develop female secondary sexual characteristics. It may also be used in certain medical conditions that require estrogen therapy, such as prostate cancer, where it can help manage symptoms and slow disease progression. However, its use should always be under the guidance of a healthcare professional.