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This medication requires careful consideration before use, as it carries potential risks and interactions that could impact your health. Please review the following information and discuss any concerns with your healthcare provider.

• Overdose and Misuse: Dextromethorphan is frequently found in various over-the-counter medications. Using more than one product containing dextromethorphan can lead to an accidental overdose, causing severe symptoms like difficulty breathing and seizures. Be mindful of other medications containing this ingredient.

• Medication Interactions: Before using dextromethorphan (Delsym), consult your healthcare provider if you are currently taking or have recently taken a monoamine oxidase inhibitor (MAOI) within the last 14 days. Additionally, inform your provider if you are taking medications that increase serotonin levels, such as certain antidepressants, as these can interact with dextromethorphan and potentially cause serotonin syndrome. This condition is serious and may present symptoms like confusion, excessive sweating, and an accelerated heart rate. Your healthcare provider can suggest alternative treatments for your cough if necessary.

• Contraindications: Avoid using this medication if you have taken a monoamine oxidase inhibitor within the last two weeks, as this could pose significant health risks. Always seek guidance from your healthcare provider if you are unsure.

Ensure you communicate openly with your healthcare provider about all medications you are taking to avoid harmful interactions and side effects.

When considering the use of Delsym, a common over-the-counter cough suppressant containing dextromethorphan, it's important to be aware of potential interactions with other substances. Combining Delsym with certain medications, alcohol, or specific foods can lead to adverse effects.

Drug Interactions:

• Monoamine Oxidase Inhibitors (MAOIs): Avoid using Delsym if you are currently taking or have recently taken MAOIs, a class of antidepressants. Combining these can increase the risk of serotonin syndrome, a serious condition characterized by symptoms such as agitation, hallucinations, rapid heartbeat, and high blood pressure.

• Selective Serotonin Reuptake Inhibitors (SSRIs) and Other Antidepressants: Medications like fluoxetine (Prozac) or sertraline (Zoloft) can interact with dextromethorphan, potentially leading to serotonin syndrome.

• Other Medications: Drugs that inhibit the enzyme CYP2D6, such as bupropion (Wellbutrin) or quinidine, can increase dextromethorphan levels in the body, raising the risk of side effects like dizziness, drowsiness, and nausea.

Alcohol Interaction:

Consuming alcohol while taking Delsym can enhance drowsiness and dizziness. Both substances depress the central nervous system, and their combined effects may impair coordination and judgment.

Food Interaction:

Grapefruit juice may increase the concentration of dextromethorphan in the bloodstream, potentially intensifying side effects such as drowsiness, dizziness, and nausea. It's advisable to limit or avoid grapefruit juice while using Delsym.

Other Considerations:

Combining Delsym with other medications that cause drowsiness, such as antihistamines (e.g., diphenhydramine), muscle relaxants, or certain pain relievers, can lead to increased sedation.

Always consult with a healthcare professional before starting Delsym, especially if you are taking other medications or have underlying health conditions. They can provide personalized advice to ensure safe and effective use.