Diethylstilbestrol

Drug Details

Diethylstilbestrol (DES) is a synthetic form of estrogen that was widely prescribed to pregnant women between 1940 and 1971 to prevent miscarriages and premature births. However, studies later revealed that DES was ineffective for these purposes and posed significant health risks. Women who took DES during pregnancy have a slightly increased risk of developing breast cancer. Their daughters, exposed to DES in utero, face a higher risk of clear cell adenocarcinoma—a rare cancer of the vagina and cervix—as well as reproductive tract abnormalities, infertility, and complications during pregnancy. Sons exposed in utero may experience testicular abnormalities, though their fertility generally remains unaffected. Additionally, there is emerging evidence suggesting that the grandchildren of women who took DES may also face health risks, including potential reproductive issues and a slightly increased risk of certain cancers. As a result of these findings, the use of DES during pregnancy was discontinued, and ongoing monitoring is recommended for those who were exposed.