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The safety information provided here is crucial for understanding the potential risks and necessary precautions when using this medication. Please read carefully and discuss any concerns with your healthcare provider.

• Restricted Use: Difluprednate (Durezol) is intended strictly for ophthalmic use. Ensure that the eye drops are applied directly to the eye and avoid applying them to any other body parts.

• Risk of Eye Infections and Problems: Prolonged use of difluprednate (Durezol) may increase the likelihood of developing new or worsening eye infections. It can also lead to eye issues such as glaucoma, cataracts, and other vision problems. Those with a history of glaucoma, cataracts, or viral infections in the eye, including herpes simplex, or those who have recently undergone cataract surgery, are at heightened risk.

• Delayed Eye Healing Post-Procedure: The use of steroid eye drops like difluprednate (Durezol) after eye surgery can impede the healing process. Inform your healthcare provider if you have recently had cataract or other eye surgeries.

• Contact Lens Precaution: Difluprednate (Durezol) contains a preservative that can be absorbed by soft contact lenses, potentially causing damage. If contact lenses are permitted during treatment, they should be removed before application of the drops. Wait a minimum of 10 minutes after instillation before reinserting your lenses.

• Contraindications: Do not use this medication if you have existing bacterial, viral, or fungal infections in the eye, as it may exacerbate these conditions. Always consult with your healthcare provider in these cases.

Common side effects:

• mild eye swelling
• redness
• pain
• sensitivity to light
• changes in the sharpness of vision
• eye itching
• eyelid irritation
• crusting on the eyelids

Serious side effects:

• new or increased eye pain
• swelling
• discharge
• redness
• discomfort in bright light
• significant changes in vision
• rash
• severe dizziness
• trouble breathing
• swelling of the face, tongue, or throat

When using difluprednate eye drops, it's important to be aware of potential interactions with other medications:

• Cyclosporine Eye Drops: Combining difluprednate with cyclosporine eye drops may enhance immune suppression, potentially increasing the risk of infections. If you're prescribed both, your doctor will monitor you closely for any signs of infection, such as fever, chills, sore throat, or unusual fatigue.

• Smallpox Vaccine: Difluprednate may interact with the smallpox vaccine. If you're scheduled to receive this vaccine, inform your healthcare provider about your use of difluprednate.

Currently, there are no known interactions between difluprednate and foods, drinks, or other medications. However, this doesn't guarantee that no interactions exist. Always inform your doctor about all medications you're taking, including over-the-counter drugs, vitamins, and herbal supplements. If you experience symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, skin redness, body sores, or pain during urination, contact your doctor immediately.