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The following guidelines outline critical safety information regarding the use of this medication. Please review these carefully and consult your healthcare provider if you have any questions or concerns.

• Increased Eye Pressure (Glaucoma): Extended use of steroid eye medications, such as loteprednol (Lotemax), may lead to elevated eye pressure (glaucoma), potentially damaging the optic nerves and impairing vision. Notify your healthcare provider immediately if you experience persistent eye pain, discomfort, or changes in vision. Regular check-ups with your provider are necessary if you are using loteprednol (Lotemax) for an extended period, especially if you have a history of glaucoma.

• Cataracts: Loteprednol (Lotemax) can contribute to the development of cataracts. Inform your healthcare provider promptly if you notice any deterioration in vision or see glares or halos around lights, especially at night. The medication is permissible after cataract removal, but usage should not exceed two weeks, with regular follow-ups advised.

• New or Worsening Infections: Steroids like loteprednol (Lotemax) can suppress the immune system, increasing the risk of fungal or viral eye infections. Steroids can also mask or exacerbate infection symptoms. Consult your provider immediately if your eye condition worsens or if symptoms do not improve within a few days. Follow-up is necessary if a refill is needed after completing the prescription. This is particularly important for individuals with a history of herpes eye infections or prolonged use of the medication.

• Eye Injury or Damage: Loteprednol (Lotemax) may cause thinning of the cornea or sclera, leading to potential tears and severe damage. The risk is heightened if you have pre-existing thin corneas or sclera or are on long-term medication use. Post-cataract surgery use may delay healing and increase the risk of blebs (fluid-filled blisters). Contact your provider if you experience eye pain, discomfort, excessive tearing, or vision deterioration.

• Contact Lens Use: Avoid wearing contact lenses if you have recently undergone eye surgery or have eye conditions like inflammation or allergies. Consult your provider regarding contact lens use while taking loteprednol (Lotemax). If permitted, remember that some forms of the medication contain benzalkonium chloride, which can damage soft lenses. Remove lenses before applying the medication and wait at least 15 minutes before reinserting them.

Contraindications:

This medication should not be used if you have any of the following conditions, as it may lead to serious health risks. Consult your healthcare provider if these apply to you:

• Eye infections caused by viruses, fungi, or mycobacteria.
• Allergy to loteprednol, other corticosteroids, or any ingredient in loteprednol (Lotemax).

When using Eysuvis (loteprednol etabonate ophthalmic suspension) for dry eye disease, it's important to be aware of potential interactions with other medications and substances. While Eysuvis is generally considered safe, certain combinations may require caution or adjustments.

Interactions with Other Eye Medications

If you're using Eysuvis alongside other eye drops, such as Artificial Tears or medications like Restasis (cyclosporine ophthalmic), it's advisable to wait at least 5 minutes between administering each medication. This interval helps prevent one drop from diluting or washing out the other, ensuring each medication works effectively.

Systemic Medication Interactions

Eysuvis is primarily applied to the eye, resulting in minimal absorption into the bloodstream. However, certain systemic medications can influence its effects:

• Immunosuppressants: Combining Eysuvis with other immunosuppressive agents, such as Restasis, may increase the risk of infections due to additive effects on the immune system. It's essential to monitor for signs of infection, including fever, chills, or unusual eye discharge.

• CYP3A4 Inhibitors: Medications like Ritonavir, Atazanavir, and levoketoconazole can elevate the levels of corticosteroids in the body. When used with Eysuvis, this may heighten the risk of systemic side effects, such as weight gain, high blood pressure, or increased blood sugar levels. If you're on these medications, discuss potential risks with your healthcare provider. (, , )

Food and Alcohol Interactions

There are no known interactions between Eysuvis and specific foods or alcohol. However, it's always a good practice to consult your doctor or pharmacist regarding dietary considerations while on any medication.

General Recommendations

Before starting Eysuvis, inform your healthcare provider about all medications you're currently taking, including prescription drugs, over-the-counter products, vitamins, and herbal supplements. This comprehensive disclosure helps prevent potential interactions and ensures the safe and effective use of Eysuvis. If you experience any unusual symptoms or side effects while using Eysuvis, contact your doctor promptly.