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This safety information outlines important considerations and potential risks associated with the use of loteprednol (Lotemax), a steroid eye medication. Please read carefully and consult your healthcare provider with any questions or concerns.

• Increased Eye Pressure (Glaucoma): Long-term use of steroid eye medications like loteprednol can increase eye pressure, potentially leading to glaucoma and nerve damage that affects vision. Notify your healthcare provider immediately if you experience persistent eye pain, discomfort, or vision changes. Regular check-ups with your provider are essential if you are using loteprednol for an extended period, especially if you have a history of glaucoma.

• Cataracts: Loteprednol can cause cataracts. If you notice worsening vision, or if lights seem to produce glares or halos, contact your provider promptly. While it is safe to use loteprednol for up to two weeks following cataract surgery, ensure regular follow-ups with your healthcare provider.

• Infections: Steroids can suppress the immune system, increasing the risk of fungal or viral eye infections. They may also alter infection symptoms, making them seem better or worse. If your eye condition worsens or does not improve within a few days of using loteprednol, consult your provider. If you finish your prescription and feel a need for a refill, a follow-up is necessary. This is particularly important if you have a history of herpes eye infections.

• Eye Damage: Steroid eye drops can thin parts of the eye like the cornea or sclera, leading to tears and more severe damage. The risk is higher if you have naturally thin corneas or sclera or if you use this medication long-term. After cataract surgery, loteprednol may slow healing and increase the risk of blebs (fluid-filled blisters) in the eye. Seek medical advice immediately if you experience eye pain, excessive tearing, or worsening vision.

• Contact Lens Use: Avoid wearing contact lenses if you have recently undergone eye surgery or are experiencing eye inflammation or allergies. Discuss with your provider whether you can wear contacts while using loteprednol. If allowed, remove soft contact lenses before applying the medication, as it contains benzalkonium chloride, which can damage lenses. Wait at least 15 minutes after applying loteprednol before reinserting your lenses.

Contraindications:

Do not use loteprednol (Lotemax) if you have:

• Viral, fungal, or mycobacterial eye infections.
• An allergy to loteprednol, other corticosteroids, or any of its ingredients.

If any of these conditions apply to you, consult your healthcare provider before using this medication.

When using Inveltys, it's important to be aware of potential interactions with other medications and certain health conditions. Inveltys may interact with 42 different drugs, with one major and 41 moderate interactions. Additionally, there are two disease interactions to consider: ocular infections and ocular toxicities.

Prolonged use of corticosteroids like Inveltys can suppress the body's immune response, increasing the risk of secondary eye infections. In acute purulent (pus-producing) eye conditions, steroids may mask or worsen existing infections. Therefore, it's crucial to inform your healthcare provider about any existing eye infections or conditions before starting Inveltys.

If you're using other eye drops alongside Inveltys, wait at least 5 minutes between applying each medication to ensure proper absorption and effectiveness. Also, remove soft contact lenses before administering Inveltys, as its preservative can be absorbed by the lenses. You can reinsert your contact lenses 15 minutes after using the eye drops.

Always consult your healthcare provider about all medications and supplements you're taking to avoid potential interactions. Regular eye examinations are recommended during treatment with Inveltys to monitor for any adverse effects or complications.