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Serious side effects of docusate are rare, but they can include severe stomach pain, cramping, or rectal bleeding. If any of these symptoms occur, it is important to seek medical attention promptly.

Docusate sodium should not be taken with mineral oil, as this combination can increase the risk of side effects. Additionally, it is advisable to consult a healthcare provider before combining docusate sodium with other medications or supplements to avoid potential interactions.

Individuals who should avoid taking docusate sodium include those with a known allergy to the medication or any of its components. Additionally, it is not recommended for individuals experiencing symptoms of appendicitis, intestinal blockage, or undiagnosed abdominal pain. Pregnant or breastfeeding individuals should consult a healthcare provider before use. It is also advised to avoid docusate sodium if there is a sudden change in bowel habits lasting more than two weeks. Always consult a healthcare professional before starting any new medication.