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It is important to be aware of the potential risks associated with estrogen use, whether taken alone or alongside another hormone like progestin. While serious side effects are rare, discussing the benefits and risks with your healthcare provider is crucial. Estrogens are not recommended for the prevention of heart disease or dementia.

Key Safety Information:

• Estrogen use is linked to an increased risk of uterine cancer (endometrial cancer). Following your doctor's guidance on taking progestin can help mitigate this risk. Report any unusual vaginal bleeding to your doctor immediately.

• Postmenopausal women using estrogen, with or without progestin, may face a heightened risk of breast and ovarian cancer, stroke, dementia, and serious blood clots. The combination of estrogen and progestin also raises the risk of heart disease, including heart attacks.

• The likelihood of serious side effects is influenced by both the estrogen dose and the duration of treatment. It is advisable to use the lowest effective dose for the shortest necessary period.

• Regular consultations with your doctor, ideally every 3 to 6 months, are essential to assess the ongoing need for this medication. If long-term use is required, ensure you undergo comprehensive physical examinations at least annually, as advised by your healthcare provider.

When using this medication, you might experience some mild side effects like skin redness or irritation at the application site, nausea, vomiting, bloating, breast tenderness, headaches, or changes in weight. These are generally not serious, but if they persist or worsen, it's important to consult with a healthcare professional.

There are some more serious side effects that require prompt medical attention. These include persistent nausea or vomiting, changes in mood or memory, the appearance of breast lumps, unusual vaginal bleeding, or increased vaginal irritation or discharge. Severe abdominal pain, yellowing of the eyes or skin, dark urine, swelling of the hands, ankles, or feet, and increased thirst or urination should also be reported immediately.

Rarely, this medication can cause serious blood clot-related issues, such as heart attacks, strokes, or clots in the lungs or legs. Watch for symptoms like chest pain, unusual sweating, sudden severe headaches, weakness on one side of the body, confusion, trouble speaking, sudden vision changes, pain or swelling in the groin or calf, shortness of breath, or sudden dizziness. These require urgent medical care.

Allergic reactions to this medication are rare but can be serious. Seek immediate help if you experience a rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing. Always report any other unusual side effects to your healthcare provider for further guidance.