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The safety and warning information provided below is crucial for anyone using this medication. It is essential to understand the potential risks and necessary precautions. For any concerns, please consult with your healthcare provider.

• Exacerbation of Pre-existing Conditions: If you have conditions such as stomach ulcers, seizures, or heart rhythm issues, be aware that these may worsen with the use of theophylline. It is important to inform your healthcare provider about any of these conditions before starting treatment.

• Theophylline Toxicity: Accumulation of theophylline in your body can pose serious health risks. Regular monitoring of blood levels is important to ensure they remain within a safe range. You may require a lower dosage if you are older, have specific health conditions, or have recently quit smoking. Persistent nausea, vomiting, or headaches could indicate excessive theophylline levels. If you experience these symptoms, contact your healthcare provider immediately and cease taking the medication until further advised. This is particularly important for:

  • Children under 1 year of age
  • Individuals aged 60 and above
  • Those with pulmonary edema, heart failure, fever lasting more than a day, hypothyroidism, liver or kidney issues, severe infections, or those who have stopped smoking.

• Interactions with Other Substances: The effectiveness and safety of theophylline can be significantly affected by other medications. High levels may be dangerous, whereas low levels may reduce efficacy. Prior to starting or stopping any new medications or supplements, consult with your healthcare provider or pharmacist to avoid any adverse interactions and to adjust the theophylline dosage if necessary.

Please adhere to these guidelines to ensure safe use of the medication and seek professional advice whenever necessary.

When taking this medication, some individuals may experience common side effects that are generally mild, such as nausea, vomiting, headaches, difficulty sleeping, stomach or abdominal pain, diarrhea, irritability, restlessness, nervousness, and increased urination. These symptoms often resemble having too much caffeine and should be monitored for persistence or worsening, in which case consulting a healthcare provider is advisable.

There are also other side effects that have been reported, including feelings of anxiety, dizziness, muscle tremors, and high uric acid levels. Some individuals may encounter abnormalities in heart rhythm or experience a fast heartbeat. Additionally, itchiness, rash, or hives may occur, and there may be issues with urination, either increased frequency or difficulty.

While serious side effects are not commonly listed, it is crucial to be aware of more severe reactions that require immediate medical attention. These include a very serious allergic reaction characterized by rash, itching or swelling, especially of the face, tongue, or throat, severe dizziness, and trouble breathing. Seizures, though very rare, also necessitate urgent medical care. If you notice any side effects not mentioned here, it is important to contact your healthcare provider for advice.

Theophylline can interact with several medications and substances. One notable interaction is with riociguat, which should generally be avoided. Additionally, viloxazine is another drug that may not be recommended for use with theophylline, but sometimes the benefits may outweigh the risks under close medical supervision.

Certain medications can change how theophylline is removed from your body, potentially altering its effects. These include cimetidine, disulfiram, fluvoxamine, mexiletine, and drugs used for seizures like carbamazepine and phenytoin, as well as St. John's wort. Smoking tobacco or marijuana can lower the levels of theophylline in your blood, so it's important to inform your doctor if you smoke or have recently quit.

Caffeine and alcohol may intensify the side effects of theophylline, so it's advisable to limit consumption of beverages with caffeine (like coffee, tea, or colas) and alcohol, as well as large amounts of chocolate and nonprescription caffeine products.

Theophylline is chemically similar to aminophylline and oxtriphylline, so these should not be used together. Additionally, theophylline may affect certain lab tests, leading to inaccurate results. Ensure that all your healthcare providers are aware you're taking this medication to prevent any issues with test results. Always inform your doctor and pharmacist about all other medications and supplements you are taking, whether they are prescription, over-the-counter, or herbal, to avoid potential interactions.