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This medication comes with important safety warnings that you should be aware of. Please read the following information carefully and speak with your healthcare provider if you have any questions or concerns.

• Exacerbation of Pre-existing Conditions: If you suffer from stomach ulcers, seizure disorders, or heart rhythm disturbances, these conditions may worsen with the use of theophylline. It is crucial to inform your healthcare provider if you have any of these medical issues.

• Risk of Theophylline Toxicity: There are several factors that can lead to dangerous levels of theophylline in your system, which can be life-threatening. Regular blood tests are necessary to ensure that your theophylline levels remain within a safe range. Elderly patients, children under one year, and those with specific health conditions such as pulmonary edema, heart failure, prolonged fever, hypothyroidism, liver or kidney issues, severe infections, or recent cessation of smoking are at increased risk. Symptoms such as persistent nausea, vomiting, or headaches may indicate excessive theophylline levels. Contact your healthcare provider immediately if you experience these symptoms and do not take any more theophylline until advised.

• Drug Interactions: Many other medications can alter the effectiveness and safety of theophylline. High levels can be dangerous, while low levels may render the medication ineffective. Always consult your healthcare provider or pharmacist before starting or stopping any other medications or supplements, as this may require adjustments to your theophylline dosage.

There are currently no specified contraindications for this medication. Always follow your healthcare provider's guidance and ensure regular monitoring through consultations and tests to maintain safe and effective use of this medication.

Common side effects:

• nausea
• vomiting
• stomach or abdominal pain
• headache
• difficulty sleeping
• diarrhea
• irritability
• restlessness
• nervousness
• shaking
• increased urination

Less common but important to monitor:

• persistent nausea or vomiting
• irregular heartbeat
• muscle cramps
• fainting
• confusion
• dizziness

Serious side effects:

• severe allergic reactions
• rash
• itching
• swelling (particularly of the face, tongue, or throat)
• severe dizziness
• trouble breathing

When taking theophylline, be aware of potential interactions with other drugs and substances. One significant drug interaction is with riociguat. Additionally, medications such as Cimetidine, Disulfiram, Fluvoxamine, and Mexiletine can alter how theophylline is eliminated from your body, potentially impacting its effectiveness. Other drugs that might affect theophylline include those used for seizures, like Carbamazepine and Phenytoin, as well as Rifampin and herbal supplements like St. John's wort.

Smoking tobacco or marijuana can lower blood levels of theophylline, so inform your doctor if you smoke or have recently quit. Be cautious with Caffeine and alcohol, as they can intensify theophylline’s side effects. It's advisable to limit consumption of caffeinated or alcoholic beverages, as well as chocolate and non-prescription products containing caffeine.

Theophylline is closely related to Aminophylline and oxtriphylline, so avoid using these medications simultaneously. Furthermore, theophylline may interfere with certain lab tests, potentially leading to inaccurate results. Ensure all healthcare providers and lab personnel are aware of your theophylline use to avoid any issues.