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This medication requires careful consideration due to potential risks and interactions. Please review the following safety information and discuss any concerns with your healthcare provider.

• Exacerbation of Existing Conditions: Individuals with stomach ulcers, seizure disorders, or heart rhythm issues may experience worsening of these conditions when using theophylline. Inform your healthcare provider if you have any of these pre-existing conditions.

• Theophylline Toxicity: Accumulation of theophylline in the body can lead to serious, life-threatening conditions. Regular monitoring of blood levels is necessary to ensure they remain within a safe range. Dosage adjustments may be needed for older adults, those with certain illnesses, or individuals who have recently quit smoking cigarettes or marijuana. Symptoms such as persistent nausea, vomiting, or headaches may indicate excessive theophylline levels. If you experience these symptoms, contact your healthcare provider immediately and refrain from taking more theophylline until they advise otherwise. Populations at increased risk include children under 1 year old, individuals aged 60 and above, and those with conditions such as pulmonary edema, heart failure, prolonged fever, hypothyroidism, liver or kidney issues, severe infections, or those who have recently stopped smoking.

• Interactions with Other Medications: Theophylline levels can be significantly affected by other medications, which may lead to life-threatening high levels or ineffective low levels. Before starting or stopping any medication or supplement, consult your healthcare provider or pharmacist to determine if adjustments to theophylline dosage are necessary.

Always follow the guidance of your healthcare provider and report any unusual symptoms or concerns promptly.

When taking this medication, some individuals may experience common side effects such as nausea, vomiting, headache, stomach or abdominal pain, trouble sleeping, diarrhea, irritability, restlessness, nervousness, and increased urination. These effects are usually mild and tend to resolve on their own. However, if they persist or worsen, it is advised to seek guidance from a healthcare provider.

While serious side effects are less common, they require prompt attention. These include persistent nausea or vomiting, unusual heartbeats (fast, slow, or irregular), muscle cramps, dizziness, fainting, or confusion. Additionally, any signs of a severe allergic reaction, such as a rash, severe dizziness, itching or swelling (especially of the face, tongue, or throat), and difficulty breathing, necessitate immediate medical assistance.

It is important to remain vigilant and report any symptoms that seem unusual or severe to your healthcare provider. This enables timely intervention and ensures your safety while using the medication.

When using theophylline, it's important to be aware of potential interactions with other medications and substances. One notable interaction is with riociguat, which should not be taken alongside theophylline. Additionally, viloxazine is another medication that may not be recommended for use with theophylline.

Certain drugs can alter how theophylline is eliminated from your body, potentially affecting its efficacy. These include Cimetidine, Disulfiram, Fluvoxamine, Mexiletine, Rifampin, and medications for seizures such as Carbamazepine and Phenytoin. St. John's wort and viloxazine are also known to interact.

Smoking cigarettes or marijuana can lower the levels of theophylline in your blood. If you smoke or have recently quit, inform your doctor. It's also advised to limit Caffeine and alcohol intake, as these can amplify the side effects of theophylline. This means reducing consumption of coffee, tea, colas, chocolate, and over-the-counter products with caffeine.

Theophylline is similar to aminophylline and oxtriphylline, so avoid taking these medications simultaneously.

Lastly, theophylline may interfere with certain laboratory tests, potentially leading to incorrect results. Ensure that all healthcare professionals involved in your care are aware that you are using theophylline.