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The use of Vismodegib, also known as Erivedge, requires careful adherence to safety guidelines due to potential risks. It is crucial for both patients and healthcare providers to understand these risks and the necessary precautions.

• Risk of Harm to Unborn Babies: Vismodegib can cause severe harm or death to an unborn child. Women who are pregnant or might become pregnant must not use this medication. Women of childbearing potential must have a negative pregnancy test within 7 days before beginning treatment and must continue using effective birth control while taking Vismodegib and for 2 years following the last dose. Men must use condoms with spermicide during sexual intercourse with women who are pregnant or may become pregnant, and continue this practice for 3 months after the last dose. Men should also refrain from donating sperm during this period. Immediate consultation with a doctor is necessary if pregnancy occurs or is suspected.

• Serious Skin Reactions: Rare but severe skin reactions, such as Stevens-Johnson syndrome (SJS) or Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), may occur. Symptoms like painful blisters, skin wounds, peeling skin, or fever require urgent medical attention.

• Muscle Issues: Muscle spasms are a common side effect, typically mild, but can be severe and indicative of tissue damage. Regular monitoring of creatine phosphokinase (CPK) levels is advised before and during treatment. Severe muscle spasms or elevated CPK levels may necessitate pausing or discontinuing the medication.

• Bone Changes in Children: Exposure to Vismodegib can lead to abnormal bone development in children. Ensure this medication is stored safely out of children's reach to prevent accidental exposure.

Patients are strongly advised to discuss any concerns with their healthcare provider to ensure safe and effective use of Vismodegib.

When taking this medication, some individuals may experience common side effects, which are generally mild and include muscle spasms, hair loss, changes in taste, weight loss, tiredness, nausea, diarrhea, reduced appetite, constipation, and joint pain. If these symptoms persist or worsen, it's advisable to consult with your healthcare provider for guidance.

Less commonly, users may experience vomiting or a loss of taste. While these side effects are not frequent, if they occur, monitoring their progression is important, and discussing them with your healthcare provider is recommended.

Though rare, serious side effects can occur and require immediate medical attention. These include severe allergic reactions characterized by fever, swollen lymph nodes, rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, and trouble breathing. Additionally, serious skin reactions may manifest as painful blisters, skin wounds, peeling skin, fever, sore throat, or body aches. If any of these symptoms appear, it is crucial to seek urgent medical care to address these potential complications. Always remain vigilant and report any unusual reactions to your healthcare provider promptly.