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This medication comes with important safety warnings that you should be aware of before starting treatment. Your healthcare provider is the best source of advice if you have any concerns. Please review the following points carefully:

• Skin Reactions: Imiquimod can cause severe skin irritation. If you notice blisters, weeping, severe peeling, or difficulty urinating due to genital swelling, contact your healthcare provider immediately. Ensure any surgical sites or areas previously treated with other medications are fully healed before using imiquimod.

• Flu-like Symptoms: Symptoms such as fever, nausea, aches, chills, or swollen lymph nodes may occur. Inform your healthcare provider immediately if these symptoms develop, as you may need to discontinue use temporarily.

• Sun Sensitivity: Imiquimod increases skin sensitivity to sunlight, sunlamps, and UV light. Avoid sun exposure and tanning. Use sunscreen and wear protective clothing if necessary. If you have a sunburn, wait for it to heal before applying imiquimod to that area. Discuss with your provider if your daily activities involve prolonged sun exposure or if you are prone to sunburn.

• Actinic Keratosis Precaution (Aldara only): The use of imiquimod on the same area of actinic keratosis for more than one treatment cycle is not well-studied. Consult your provider if the condition persists or recurs after treatment. Avoid using this medication on large areas without your provider's guidance.

• Specific Use for Skin Cancer (Aldara only): Imiquimod is intended for basal cell carcinoma on the skin's surface of the torso, neck, arms (excluding hands), or legs (excluding feet). It is not suitable for skin cancer on the face, head, anus, or genitals, or for more severe types. Regular follow-ups with your provider are necessary to monitor healing.

• Ineffectiveness for HPV (Aldara only): Imiquimod does not cure HPV, and new warts can still form and be contagious. Discuss any concerns regarding HPV with your provider.

• Use with Other Imiquimod Products (Zyclara only): Consult your provider before using multiple imiquimod products to avoid increased and severe side effects.

• Autoimmune Conditions (Zyclara only): Imiquimod can activate immune cells, potentially causing a flare-up in individuals with autoimmune diseases. Discuss your condition with your provider before starting treatment.

No contraindications are provided for this medication. Always discuss your medical history and current medications with your healthcare provider to ensure safe use.

Common side effects:

• Redness of the skin
• Swelling of the skin
• Itching of the skin
• Burning of the skin
• Pain in the skin
• Thickening or hardening of the skin
• Peeling of the skin
• Flaking of the skin
• Scabbing of the skin
• Crusting of the skin
• Clear fluid leakage from the skin
• Runny or stuffy nose
• Cough
• Diarrhea
• Nausea
• Back pain

Less common but important to monitor:

• Fatigue
• Dizziness
• Fever
• Viral infections
• Chills
• Eczema
• Hair loss
• Headache
• Vomiting
• Urinary tract infections

Serious side effects:

• Bleeding of the skin
• Sores on the skin
• Blisters on the skin
• Ulcers on the skin
• Flu-like symptoms
• Swollen lymph nodes
• Unusual skin growths or changes
• Chest pain
• Difficulty urinating due to genital swelling
• Allergic reactions with rash, itching, or swelling
• Severe dizziness
• Trouble breathing
• Atrial fibrillation

Imiquimod is a topical medication primarily used to treat certain skin conditions, including actinic keratosis, superficial basal cell carcinoma, and external genital warts. While it is applied to the skin and has minimal systemic absorption, it's important to be aware of potential interactions with other treatments and medications.

Concurrent Topical Treatments: Using imiquimod alongside other topical agents, especially those that can irritate the skin, may increase the risk of adverse skin reactions. It's advisable to allow the skin to heal from any previous treatments or surgeries before starting imiquimod therapy.

Photosensitizing Agents: Combining imiquimod with medications that increase sensitivity to sunlight, such as porfimer, can heighten the risk of photosensitivity reactions. These reactions may include redness, swelling, itching, burning sensations, or blistering upon exposure to sunlight or bright indoor lights. To minimize this risk, it's recommended to avoid using imiquimod for at least 30 days after completing therapy with photosensitizing agents and until a test confirms no residual photosensitivity.

Immunosuppressive Drugs: Imiquimod works by stimulating the immune system. Therefore, using it in conjunction with immunosuppressive medications may alter its effectiveness or increase the likelihood of adverse effects. It's essential to inform your healthcare provider about all medications you're taking, including immunosuppressants, to ensure safe and effective use of imiquimod.

Contraceptive Devices: Imiquimod may weaken latex condoms and vaginal diaphragms, potentially reducing their effectiveness. Therefore, alternative contraceptive methods are recommended during treatment.

Always consult your healthcare provider before starting or combining treatments to ensure safety and efficacy.