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The following provides critical safety and warning information for medications containing acetaminophen, such as Excedrin Migraine. It is essential to understand these risks and take necessary precautions. Consult your healthcare provider if you have any concerns or questions.

• Liver Damage: Excessive intake of acetaminophen can lead to severe, potentially fatal liver damage. Adults should not exceed 4000 milligrams (4 grams) in 24 hours. If you have liver issues or are a child, consult your healthcare provider for safe dosage. Do not use other products containing acetaminophen without professional guidance, as it is present in many over-the-counter and prescription medications. Avoid combining with alcohol, as this increases liver damage risk.

• Reye's Syndrome in Children: Aspirin in Excedrin Migraine can cause Reye's syndrome, a rare but serious condition, in children recovering from viral infections. It manifests with symptoms like vomiting and confusion, potentially progressing to seizures. Avoid Excedrin Migraine for children with flu-like symptoms or chickenpox. Seek alternatives from your child's healthcare provider.

• Allergic Reactions: Severe allergic reactions, including anaphylaxis, can occur with Excedrin Migraine. Symptoms include hives, breathing difficulties, and swelling of the lips or tongue. Contact emergency services immediately if these occur. Inform your healthcare provider about any known allergies to aspirin or NSAIDs.

• Stomach Bleeding and Ulcers: Aspirin may irritate the stomach, causing heartburn or more severe issues like bleeding and ulcers. Symptoms include persistent stomach pain, vomiting blood, or black stools. Stop using the medication and seek medical help if these symptoms arise. Risk factors include a history of stomach problems, concurrent use of NSAIDs, blood thinners, alcohol, or being over 60 years old.

• Kidney Problems: Aspirin in Excedrin Migraine might cause kidney damage, particularly if you have existing kidney issues or take certain blood pressure medications. Symptoms to watch for include reduced urination, fever, or numbness. Consult your provider if these symptoms occur.

• Dehydration: The caffeine in Excedrin Migraine can lead to dehydration, especially at high doses. Symptoms include dry mouth and dizziness. Ensure adequate hydration and consult your provider if dehydration symptoms develop.

• Worsening of Medical Conditions: Excedrin Migraine may exacerbate existing health conditions, such as liver or kidney problems, heart disease, or high blood pressure. Discuss your medical history with your provider before starting this medication.

• Accidental Overdose: Overconsumption of acetaminophen or NSAIDs can lead to severe health risks, including liver damage, bleeding, and heart problems. Be vigilant about the cumulative intake of these substances from various medications and consult your provider for guidance. In case of overdose, seek immediate medical assistance or contact the Poison Control Center.

Contraindications: Consult your healthcare provider before using Excedrin Migraine if you have:

• An allergy to aspirin or other NSAIDs.
• Asthma, nasal inflammation, or nasal polyps.
• Are under 18 years of age, as Excedrin Migraine is not recommended for children.
• Are using other acetaminophen-containing products.

Always follow professional medical advice and refer to your healthcare provider for any clarifications or concerns regarding medication use.

When taking this medication, some common side effects may include nausea, vomiting, stomach upset, difficulty sleeping, and feelings of nervousness or restlessness. These effects are often mild, but if they persist or worsen, it is advisable to consult with a healthcare provider for further guidance.

There are also more serious side effects that require immediate medical attention. These include severe stomach or abdominal pain, dizziness, fainting, vomiting that resembles coffee grounds, and black or bloody stools. Additionally, signs of bleeding, such as unusual bruising or bleeding gums, should be promptly addressed. Hearing issues, such as ringing in the ears or loss of hearing, as well as signs of kidney problems like changes in urine output, require urgent care.

Though rare, severe allergic reactions are possible and demand quick medical intervention. Symptoms can include fever, swollen lymph nodes, rash, severe dizziness, and trouble breathing, especially if associated with swelling of the face, tongue, or throat. Liver problems may manifest as dark urine, yellowing of the skin or eyes, and extreme fatigue. Kidney issues might show as reduced urine output or bloody urine.

In extremely rare cases, severe dehydration, skin reactions like blisters, peeling, or red patches, and serious liver or kidney injuries may occur. If you experience any of these severe side effects, it is critical to seek urgent medical attention to address these conditions promptly.

This medication can interact with several other drugs. Specifically, it may interact with acetazolamide, cimetidine, corticosteroids like prednisone, dichlorphenamide, ketoconazole, levoketoconazole, methotrexate, mifepristone, some gout medications such as probenecid, anti-seizure drugs like phenytoin and valproic acid, and vemurafenib. If you have recently received certain live vaccines, such as the varicella or intranasal influenza vaccine, consult your doctor before using this medication.

There is an increased risk of bleeding when this medication is taken with other drugs that can also cause bleeding. This includes anti-platelet medications like clopidogrel and blood thinners such as dabigatran, enoxaparin, and warfarin. Additionally, be cautious of taking it with other pain relievers or fever reducers, including acetaminophen, aspirin, and NSAIDs like ibuprofen, ketorolac, and naproxen, as they are similar and may heighten side effects.

This medication may affect certain laboratory tests, such as those for urinary sugar and dipyridamole-thallium imaging, potentially resulting in incorrect results. Ensure that all medical personnel and your healthcare providers are aware that you are taking this medication. Always check with your doctor or pharmacist if you have any questions about potential interactions with your current medications.