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This document provides essential safety information about the potential risks and necessary precautions when using Reyvow (lasmiditan). It is crucial to understand these warnings and to discuss any concerns with your healthcare provider.

• Dizziness and Sleepiness: Reyvow (lasmiditan) may cause dizziness and drowsiness. These effects can be intensified if you consume alcohol or take other sedative medications, such as opioids or benzodiazepines. It is advised to avoid such combinations to prevent increased dizziness and sleepiness.

• Serotonin Syndrome: There is a risk of developing a rare but serious condition known as serotonin syndrome, which occurs due to an excess of serotonin in the brain. This condition may arise if Reyvow (lasmiditan) is taken alongside other medications that increase serotonin levels. Be vigilant for symptoms and consult with your healthcare provider if such medications are part of your treatment plan.

• Medication-Overuse Headache: Excessive use or frequent administration of migraine medications, including Reyvow (lasmiditan), can reduce their effectiveness and potentially lead to medication-overuse headaches. This may result in more frequent migraine-like headaches. It is important to adhere to prescribed dosages and usage instructions to avoid this risk.

There are no specific contraindications noted for Reyvow (lasmiditan) at this time. Always consult with your healthcare provider to ensure safe use of this medication, particularly if you are taking other substances or have pre-existing health conditions.

When taking this medication, some common side effects may occur, but they are generally mild and manageable. These include dizziness, which affects up to 17% of users, numbness or a tingling sensation felt by up to 9%, sleepiness noted in up to 7%, and tiredness in up to 6%. If these effects last or become bothersome, it is advisable to consult your healthcare provider. Other reported side effects include nausea, vomiting, muscle weakness, vertigo, vision changes, heart palpitations, slower heart rate, increased blood pressure, and sleep disturbances. Monitoring your blood pressure is important as this medication can elevate it.

It is crucial to be aware of more severe side effects, albeit rare, that require immediate medical attention. These include serotonin syndrome, a serious condition characterized by fast heart rate, fever, severe dizziness, sweating, flushing, tremors, muscle stiffness or twitching, uncoordinated movements, and hallucinations. Additionally, be vigilant for signs of a serious allergic reaction, such as rash, swelling especially of the face, lips, or tongue, and difficulty breathing. If you experience any of these severe symptoms, seek urgent medical care. Always report any other unusual effects to your healthcare provider for further guidance.

Taking certain medications alongside others that increase serotonin levels can heighten the risk of serotonin syndrome, a potentially serious condition. Drugs that may lead to this interaction include recreational substances like MDMA (commonly known as "ecstasy"), herbal supplements such as St. John's wort, and some antidepressants, specifically SSRIs (e.g., fluoxetine, paroxetine) and SNRIs (e.g., duloxetine, venlafaxine). Additionally, MAO inhibitors, including isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, and tranylcypromine, are known to contribute to this risk. The likelihood of serotonin syndrome may increase particularly when starting or raising the doses of these medications.

It's essential to inform your doctor or pharmacist about any other products you are using that may induce drowsiness. These include opioid pain or cough medications (such as codeine and hydrocodone), alcohol, cannabis, medications for sleep or anxiety (such as alprazolam, lorazepam, and zolpidem), muscle relaxants (like carisoprodol and cyclobenzaprine), and antihistamines (including cetirizine and diphenhydramine). Always check medicine labels, especially for products treating allergies or cold symptoms, as they might contain drowsiness-inducing components. Consult your pharmacist for advice on safely using these products together.