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This medication carries several important safety considerations that both patients and healthcare providers should be aware of. It is crucial to understand the potential risks and precautions associated with its use. Please review the following information and consult your healthcare professional if you have any questions or concerns:

• Reduced Blood Flow Risks: This medication may rarely cause significant reduction in blood flow to the arms, hands, feet, or brain, potentially leading to a stroke. The risk increases when taken with drugs that affect the elimination of ergotamine from the body. Avoid using it in combination with certain medications such as protease inhibitors (commonly used for HIV treatment), macrolide antibiotics (e.g., erythromycin, clarithromycin), and other medications like mifepristone, telithromycin, certain antidepressants (e.g., nefazodone), azole antifungals (e.g., ketoconazole, itraconazole), cobicistat, and SSRIs (e.g., fluoxetine, paroxetine, fluvoxamine). Always inform your healthcare provider of all medications you are currently taking to ensure safety. Seek immediate medical attention if you experience symptoms like pain, numbness, coldness in your limbs, or any signs of a stroke, such as weakness or slurred speech.

• Fibrosis Risk: There have been rare reports of fibrosis (scarring) occurring in the stomach, lungs, or heart. Use this medication only as prescribed and not on a daily basis. If frequent use is necessary, discuss alternative headache treatments with your healthcare provider.

• Allergic Reactions: This medication contains yellow #5 dye (tartrazine), which may cause allergic reactions in some individuals, including airway tightening and breathing difficulties. If you have known allergies to tartrazine or yellow dyes, consult your healthcare provider.

Contraindications: Do not use this medication if you are currently pregnant, have blood vessel problems in your limbs, heart disease, high blood pressure, liver or kidney disease, or a serious infection (sepsis). Additionally, avoid it if you are taking medications that could increase its levels in your body, such as macrolide antibiotics and protease inhibitors.

In case of an overdose, seek emergency medical assistance immediately. It is vital to follow the prescribed dosage and consult your healthcare team for any concerns regarding interactions or side effects related to this medication.

When taking this medication, some common side effects may include nausea, vomiting, an upset stomach, restlessness, trouble sleeping, and dizziness. These effects are usually mild, but if they persist or worsen, it is important to consult a healthcare provider.

There are also other side effects that some users have reported, which may include muscle pain, tingling or numbness in the fingers or toes, cold hands or feet, and changes in heartbeat, such as a fast or slow heart rate. Some individuals may experience a sensation of the room spinning, swelling due to fluid buildup, or itching. In rare cases related to specific forms of the medication, such as suppositories, rectal ulcers may occur.

Serious side effects, although rare, require immediate medical attention. These include symptoms of a stroke, such as weakness on one side of the body, slurred speech, or a drooping face. Additionally, signs of poor blood flow to the hands or feet, which may present as pain, numbness, coldness, or a pale color, should not be ignored. Severe allergic reactions are also rare but require urgent care if symptoms like rash, itching/swelling, severe dizziness, or trouble breathing occur.

If any unfamiliar side effects appear, discussing them with a healthcare professional is advisable to ensure safe use of the medication.