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When considering the use of iloperidone (Fanapt), it is crucial to be aware of the associated safety information and warnings. This medication carries potential risks, and it is important to discuss these with your healthcare provider to ensure a clear understanding of its effects and any necessary precautions. Below are key points to consider:

• Increased Risk for Older Adults with Dementia: There is a heightened risk of severe side effects, such as heart failure, stroke, and infections, in older adults with dementia-related conditions. Iloperidone (Fanapt) is not advised for individuals aged 65 and older with dementia-related psychosis due to these risks.

• Heart Rhythm Concerns (QT Prolongation): Iloperidone can cause significant heart rhythm issues, known as QT prolongation. Risks are increased if you have a history of heart problems, low electrolyte levels, or are taking other medications affecting heart rhythm. Seek immediate medical help if experiencing symptoms like chest pain, shortness of breath, or fainting.

• Risk of Neuroleptic Malignant Syndrome: This medication may trigger a rare but critical condition characterized by symptoms such as fever, muscle stiffness, and confusion. Prompt medical attention is necessary if these symptoms appear.

• Metabolic Changes: Iloperidone can lead to weight gain, increased blood sugar, and cholesterol levels. Regular monitoring through blood tests and maintaining a healthy lifestyle are recommended.

• Movement Disorders: There is a risk of developing tardive dyskinesia, which involves uncontrolled movements. Early detection and consultation with a healthcare provider are crucial to prevent permanency.

• Blood Pressure and Fall Risk: The medication may cause dizziness or low blood pressure, leading to falls. Caution is advised when changing positions from sitting or lying down.

• Infection Risk: A possible decrease in white blood cells may increase infection susceptibility. Regular blood tests are advised to monitor white blood cell levels.

• Seizure Potential: Individuals with a history of seizures should discuss their condition with a healthcare provider before starting iloperidone.

• High Prolactin Levels: This can result in reproductive health issues and irregular menstrual cycles, necessitating monitoring during treatment.

• Drowsiness and Concentration Issues: The medication can cause significant drowsiness and impair concentration. Combining it with other sedative substances, including alcohol, increases these effects.

• Prolonged Erection Alert: Rarely, iloperidone may cause prolonged erections. Immediate medical attention is required if an erection lasts over four hours.

• Surgical Considerations: If planning cataract or glaucoma surgery, inform your ophthalmologist if you are using iloperidone, as it may affect the procedure.

Always consult your healthcare provider with any concerns or before starting or stopping any medication.

When taking this medication, you may encounter common side effects such as dizziness, sleepiness, dry mouth, tiredness, stuffy nose, and weight gain. These effects are usually mild and tend to improve as your body adjusts to the medication. However, if they persist or worsen, it is advisable to consult a healthcare professional. A fast heart rate and nausea are also noted among common experiences.

Be aware that this medication can cause a significant drop in blood pressure, especially when starting or increasing the dose, leading to dizziness and lightheadedness, which can increase the risk of falls. Rising slowly from sitting or lying positions can help mitigate these effects.

More severe side effects require immediate medical attention. These include symptoms like drooling, trouble swallowing, persistent cough, fever, tremors, muscle spasms, and interrupted breathing during sleep. Rarely, this medication may lead to involuntary muscle movements known as tardive dyskinesia, which could become permanent. Other serious concerns include the potential for increased blood sugar levels, which may affect diabetes management, and elevated prolactin levels, which can cause reproductive issues in both males and females.

In extremely rare cases, serious conditions such as neuroleptic malignant syndrome (NMS) or severe allergic reactions may occur. Symptoms of NMS include fever, severe muscle stiffness, confusion, irregular heartbeat, and changes in urine production. Allergic reactions might present as rash, itching, swelling, severe dizziness, or breathing difficulties. Seek immediate medical assistance if any of these symptoms develop. Additionally, males may experience a painful or prolonged erection lasting four or more hours, which requires prompt medical intervention to prevent lasting damage. Always remain vigilant about side effects and consult with healthcare providers to ensure safe use of the medication.

When taking iloperidone (Fanapt), it's important to inform your doctor and pharmacist about all medications and supplements you are using, including prescription, over-the-counter, and herbal products. Certain medications can interact with iloperidone, potentially affecting its effectiveness or increasing side effects.

Some drugs, like alpha blockers (e.g., prazosin) and various antidepressants (e.g., nefazodone), can impact how iloperidone is processed in your body. Additionally, many medications can influence heart rhythm, leading to QT prolongation. These include amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, and certain antibiotics like erythromycin.

Avoid using iloperidone with drugs such as Bepridil, Bromopride, Cisapride, and others listed, as these combinations are not recommended. In some cases, your healthcare provider may determine that using iloperidone with certain medications is necessary, but they will carefully adjust dosages and monitor you for any adverse effects. These medications include amiodarone, aripiprazole, and erythromycin, among others.

Also, be cautious with other products that cause drowsiness, including opioid pain relievers (e.g., codeine, hydrocodone), alcohol, cannabis, sleep or anxiety medications (e.g., alprazolam, lorazepam), muscle relaxants (e.g., carisoprodol, cyclobenzaprine), and antihistamines (e.g., cetirizine, diphenhydramine). Always check medicine labels for ingredients that might cause drowsiness and consult your pharmacist for safe use.