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When considering the use of Secuado (asenapine), it is crucial to understand the potential risks and precautions associated with this medication. This information is intended to help you make informed decisions about your treatment in collaboration with your healthcare provider.

• Increased Risk in Older Adults with Dementia: Older adults with dementia-related psychosis may face a higher risk of serious side effects, including death, stroke, heart problems, or infections when using antipsychotic medications like Secuado. This medication is not approved for treating dementia-related behavior problems. Discuss alternatives with your doctor.

• Neuroleptic Malignant Syndrome (NMS): This rare, but potentially fatal condition, can occur with antipsychotic use. Symptoms include high fever, confusion, fast heart rate, and muscle stiffness. Seek immediate medical attention if these symptoms occur.

• Tardive Dyskinesia (TD): Long-term use of Secuado can lead to uncontrolled muscle movements. This risk is higher in older adults, women, and those on prolonged or high-dose treatment. Some symptoms may persist even after discontinuation of the medication.

• Metabolic Changes: Secuado can increase blood sugar, cholesterol, and cause weight gain. Regular monitoring of blood sugar levels is recommended, especially if you have a history of diabetes or high cholesterol.

• Allergic Reactions: Serious allergic reactions are possible, even after the first dose. Symptoms like rash, rapid heartbeat, facial or tongue swelling, difficulty breathing, or anaphylaxis require urgent medical care.

• Low Blood Pressure and Risk of Falls: Secuado may cause dizziness or lightheadedness, increasing fall risk. Stand up slowly and support yourself to minimize these effects, especially at the start of treatment or after dosage changes.

• Low White Blood Cell Count: This medication can reduce white blood cell levels, increasing infection risk. Be cautious if you have a history of low white blood cells or are using other medications with similar effects.

• Heart Rhythm Changes: There is uncertainty about Secuado’s impact on heart rhythm, but potential risks exist, especially if you have a history of arrhythmia or are taking other heart-affecting medications.

• High Prolactin Levels: Asenapine may elevate prolactin, leading to menstrual changes, sexual issues, enlarged male breasts, or breast discharge. Consult your healthcare provider if you experience these symptoms.

• Seizure Risk: Individuals with a history of seizures should use Secuado cautiously. The risk is higher for those over 65 or with conditions predisposing them to seizures. Discuss any concerns with your healthcare provider.

• Contraindications: Do not use Secuado if you have severe liver problems or are allergic to asenapine sublingual tablets. Always consult with your healthcare provider if you have any of these conditions.

In case of overdose or severe side effects, seek emergency medical attention immediately. Always discuss your medical history and any other medications you are taking with your healthcare provider to ensure safe use of Secuado.

When taking this medication, some common side effects might occur, such as redness, itching, pain, or irritation at the application site. You might also experience drowsiness, dizziness, lightheadedness, or weight gain. If these effects persist or worsen, it is advisable to contact your healthcare provider. To reduce dizziness and lightheadedness, rise slowly from sitting or lying positions to prevent falls.

Severe side effects require immediate attention. Report any muscle stiffness, tremors, restlessness, mask-like facial expressions, drooling, trouble swallowing, or shuffling walk to your doctor. Rarely, this drug can cause uncontrollable movements like lip smacking, mouth puckering, or unusual arm and leg movements, which may be permanent. High blood sugar is another potential side effect, so watch for increased thirst and urination.

In some cases, the medication may elevate prolactin levels, leading to symptoms such as unwanted breast milk production, missed periods, or sexual difficulties. Males might rarely experience a prolonged erection, which requires urgent medical intervention to prevent lasting damage.

Other serious side effects include interrupted breathing during sleep, signs of infection, severe dizziness, fainting, a slow heartbeat, or seizures. A rare but serious condition called neuroleptic malignant syndrome (NMS) can occur, presenting with symptoms like fever, muscle stiffness, severe tiredness, confusion, sweating, and irregular heartbeat.

Allergic reactions are rare but serious. Seek immediate medical help if you notice symptoms like rash, severe dizziness, swelling, or trouble breathing. This list does not cover all possible side effects, so contact your healthcare provider if you experience any new or concerning symptoms.