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First-Progesterone VGS is a medication containing progesterone, a hormone essential for regulating ovulation and menstruation. While it is beneficial for various medical conditions, certain risks are associated with its use.

Individuals with a history of stroke, blood clots, or circulation problems should avoid using First-Progesterone VGS, as it may increase the risk of these conditions. Similarly, those with liver disease, breast or uterine cancer, or unexplained vaginal bleeding are advised against its use. If you have recently experienced an ectopic pregnancy or an incomplete abortion, this medication may not be suitable for you.

Using First-Progesterone VGS can elevate the risk of developing blood clots, stroke, heart attack, or breast cancer. It's important to discuss these potential risks with your healthcare provider to determine if this medication is appropriate for your situation.

Some forms of vaginal progesterone may contain plant-based oils. If you have food allergies, particularly to plant oils, inform your doctor before starting this medication.

If you are pregnant, do not use First-Progesterone VGS unless it is prescribed as part of your fertility treatment. Inform your doctor if you become pregnant during treatment. Additionally, progesterone can pass into breast milk, so consult your healthcare provider if you are breastfeeding.

Before starting First-Progesterone VGS, disclose your full medical history to your doctor, including any conditions like high blood pressure, heart disease, migraines, asthma, kidney disease, seizures, or a history of depression. This information will help your healthcare provider assess the suitability and safety of this medication for you.

FIRST-Progesterone VGS is a vaginal progesterone medication used to support pregnancy and treat certain menstrual disorders. While many individuals tolerate this medication well, some may experience side effects. Common side effects include:

• Headache
• Breast tenderness or enlargement
• Bloating or gas
• Stomach pain
• Nausea or vomiting
• Constipation or diarrhea
• Fatigue or drowsiness
• Muscle, joint, or bone pain
• Mood swings or irritability
• Vaginal discharge or discomfort
• Changes in sexual desire
• Difficulty sleeping These side effects are generally mild and may diminish as your body adjusts to the medication. Serious side effects are less common but require immediate medical attention. These include:
• Sudden, severe headache
• Dizziness or fainting
• Slurred speech
• Weakness or numbness in an arm or leg
• Loss of coordination or balance
• Shortness of breath
• Sharp chest pain
• Coughing up blood
• Swelling or pain in the legs
• Vision changes, such as loss of vision or double vision
• Unexpected vaginal bleeding
• Depression
• Yellowing of the skin or eyes
• Hives, rash, or itching
• Difficulty breathing or swallowing
• Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs If you experience any of these serious side effects, stop using the medication and seek medical attention immediately. It's important to discuss any concerns or side effects with your healthcare provider to ensure the safe and effective use of FIRST-Progesterone VGS.

When using FIRST-Progesterone VGS, it's important to be aware of potential interactions with other medications and substances:

• Enzyme-Inducing Drugs: Medications such as Carbamazepine, griseofulvin, Phenobarbital, Phenytoin, and Rifampin can enhance the body's metabolism of progesterone. This may reduce the effectiveness of FIRST-Progesterone VGS. If you're taking any of these drugs, consult your healthcare provider to discuss possible adjustments to your treatment plan.

• Ketoconazole: This antifungal agent may increase progesterone levels in the blood, potentially leading to heightened effects or side effects. Inform your doctor if you're using ketoconazole so they can monitor your response to therapy.

• Cyclosporine: Progesterone might inhibit the metabolism of cyclosporine, an immunosuppressant, resulting in increased blood levels of cyclosporine. This can raise the risk of cyclosporine-related side effects. Regular monitoring of cyclosporine levels is advisable when used concurrently with progesterone.

• Grapefruit Juice: Consuming grapefruit juice may elevate the plasma concentrations of orally administered drugs metabolized by the CYP3A4 enzyme, including progesterone. This interaction is due to grapefruit juice's ability to inhibit this enzyme, leading to increased drug levels. It's recommended to avoid grapefruit juice while taking FIRST-Progesterone VGS to prevent potential side effects.

• Alcohol and Caffeine: While specific interactions with progesterone are not well-documented, it's generally advisable to limit alcohol and caffeine intake during treatment. These substances can influence the effectiveness of medications and may exacerbate side effects.

Always inform your healthcare provider about all medications, supplements, and herbal products you're currently using. This ensures they can provide guidance tailored to your specific health needs and help you avoid potential interactions.