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Flurbiprofen, a nonsteroidal anti-inflammatory drug (NSAID), carries certain risks that should be carefully considered. It is important to be aware of the following safety information:

• Increased Cardiovascular Risk: This medication may rarely elevate the risk of heart attack or stroke. This risk can occur at any time during treatment but is more pronounced with prolonged use. Individuals who are older or have pre-existing heart conditions, or risk factors such as smoking, a family history of heart disease, high blood pressure, or diabetes, may be at heightened risk. It is advised not to use this drug immediately before or after heart bypass surgery (CABG).

• Gastrointestinal Bleeding: There is a rare possibility of severe and potentially fatal bleeding in the stomach or intestines, which can occur without prior symptoms. This risk is particularly increased in older adults.

• Immediate Medical Attention: Discontinue use and seek medical attention if you experience any of the following serious side effects: persistent stomach or abdominal pain, black or tarry stools, vomit resembling coffee grounds, chest, jaw, or left arm pain, difficulty breathing, unusual sweating, confusion, weakness on one side of the body, speech difficulties, or sudden changes in vision.

Consult your doctor or pharmacist to thoroughly discuss the benefits and risks associated with taking flurbiprofen. This ensures that you have a comprehensive understanding of how this medication may affect you based on your health profile.

You might experience some mild side effects such as an upset stomach, diarrhea, heartburn, nausea, dizziness, or drowsiness. These are generally not serious and often improve on their own. However, if they persist or worsen, it is important to inform your healthcare provider. While using this medication, it's also advisable to monitor your blood pressure regularly, as it may result in increased levels. Notify your healthcare provider if you notice any significant changes.

There are more serious side effects that require immediate medical attention. These include changes in hearing (like ringing in the ears), mood changes, unusual bleeding or bruising, difficulty swallowing, or signs of kidney issues such as changes in urine output. Additionally, watch for symptoms of heart failure, including swelling of the ankles or feet, unusual tiredness, or sudden weight gain.

Flurbiprofen may rarely lead to severe liver damage, which can be life-threatening. Seek urgent medical help if you experience persistent nausea or vomiting, loss of appetite, abdominal pain, yellowing of the eyes or skin, or dark urine. Though a severe allergic reaction to this medication is uncommon, it is critical to seek immediate medical attention if you experience symptoms such as fever, swollen lymph nodes, rash, severe dizziness, or difficulty breathing.

This summary includes common and serious side effects, but it's important to be aware that other effects may occur. Keep in touch with your healthcare provider regarding any unusual symptoms you may experience.

Certain medications can interact with this drug. These include Aliskiren; ACE inhibitors like Captopril and Lisinopril; angiotensin II receptor blockers such as Losartan and Valsartan; Cidofovir; corticosteroids like Dexamethasone and Prednisone; Lithium; Methotrexate; and diuretics, commonly known as "water pills," including Furosemide. This medication may also heighten the risk of bleeding when used with other drugs that have a similar effect, such as anti-platelet medications like Clopidogrel and anticoagulants or "blood thinners" like Dabigatran, Enoxaparin, and Warfarin.

It is crucial to thoroughly review the labels of all your prescription and over-the-counter medications, as many contain pain relievers or fever reducers like Aspirin and NSAIDs such as Ibuprofen, Ketorolac, and Naproxen. These medications are similar to flurbiprofen and taking them together may increase the likelihood of experiencing side effects. If your healthcare provider has advised you to take low-dose aspirin (typically 81-162 milligrams daily) to help prevent a heart attack or stroke, continue taking it unless instructed otherwise by your doctor. For further guidance, consult with your doctor or pharmacist.