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This document outlines important safety information and warnings associated with the use of meclofenamate. It is crucial to understand these details to ensure safe use of the medication. Discuss any concerns with your healthcare provider.

• Heart Attack and Stroke Risk: Meclofenamate may increase the chance of blood clots, heart attacks, or strokes, especially within the initial weeks of treatment. Those with pre-existing heart conditions, using high doses, or on long-term treatment have heightened risks. Avoid use around coronary artery bypass surgery. Symptoms prompting immediate medical attention include chest pain, breathing difficulties, sudden weakness, and speech or mobility issues.

• Stomach Bleeding and Ulcers: The drug can lead to severe stomach bleeding and ulcers without prior symptoms. The risk is higher in older adults and those with a history of such conditions or who use other NSAIDs, corticosteroids, blood thinners, or consume alcohol. If you experience persistent stomach pain, black stools, or blood in vomit, discontinue use and contact your doctor immediately.

• High Blood Pressure and Heart Failure: Meclofenamate can cause fluid retention, potentially elevating blood pressure or risking heart failure. Inform your doctor about any heart disease or blood pressure medication to assess suitability. Signs like unexplained fainting, activity-related chest pain, or irregular heartbeat require prompt medical evaluation.

• Kidney Damage: This medication can impair kidney function, with increased risk for older adults, diabetics, or those on certain medications. Regular kidney function tests may be necessary. Watch for symptoms like changes in urination, fatigue, dry skin, low appetite, and muscle cramps and report them to your healthcare provider.

• Severe Allergic Reactions: Serious allergic responses, including anaphylaxis, can occur. If you have a history of allergic reactions to aspirin or other NSAIDs, inform your doctor. Signs of a severe reaction, such as hives, rash, swelling, or breathing difficulties, require urgent medical attention.

• Pregnancy and Breastfeeding: Meclofenamate may harm an unborn child if taken after the first half of pregnancy and is not recommended during breastfeeding. Discuss potential risks and benefits with your healthcare provider before use.

Contraindications:

• Do not use meclofenamate if allergic to NSAIDs or if you have experienced asthma or allergic reactions following NSAID or aspirin use. Avoid after coronary artery bypass graft surgery. Always consult your healthcare provider if any contraindications apply to your health situation.

Common side effects:

• upset stomach
• diarrhea
• nausea
• vomiting
• gas
• heartburn
• dizziness
• drowsiness
• headache
• increase in blood pressure

Serious side effects:

• changes in hearing
• mental or mood changes
• easy bleeding or bruising
• painful or difficult swallowing
• signs of kidney problems (changes in urine output or pink/bloody urine)
• symptoms of heart failure (swelling of ankles or feet, unusual tiredness, sudden weight gain)
• severe liver issues (persistent nausea or vomiting, loss of appetite, abdominal pain, yellowing of skin or eyes, dark urine)
• serious allergic reactions (fever, swollen lymph nodes, rash, itching, severe dizziness, trouble breathing)
• stomach bleeding
• heart attack
• stroke
• kidney issues (tiredness, dry skin, reduced urination)
• serious skin reactions (reddening, blisters, rash)

Interactions with high risk of serious adverse effects and should be avoided:

• Cidofovir
• Lithium
• Methotrexate
• Anti-platelet drugs (e.g., clopidogrel) and anticoagulants ('blood thinners' such as dabigatran, enoxaparin, warfarin)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Aliskiren, ACE inhibitors (e.g., captopril, lisinopril), and Angiotensin II receptor blockers (e.g., losartan, valsartan)
• Corticosteroids (e.g., dexamethasone, prednisone)
• Diuretics ('water pills' like furosemide)

Interactions with low risk that usually do not require a change in therapy:

• Pain relievers/fever reducers (e.g., aspirin, NSAIDs like ibuprofen, ketorolac, naproxen)