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Celecoxib, like other nonsteroidal anti-inflammatory drugs (NSAIDs), comes with important safety considerations that should be reviewed before use. Below are the key points to ensure safe administration:

• Increased Risk of Heart Attack or Stroke: Celecoxib may elevate the risk of heart attack or stroke, which can occur anytime during treatment. This is especially pertinent for individuals with a history of heart disease or risk factors such as smoking, high blood pressure, diabetes, or advanced age. Avoid using celecoxib immediately before or after heart bypass surgery (CABG).

• Potential for Stomach and Intestinal Bleeding: Celecoxib can lead to severe and possibly fatal stomach or intestinal bleeding, which may occur without warning. This risk is heightened in older adults and those with a history of ulcers or stomach bleeding. Symptoms requiring immediate medical attention include persistent stomach pain, black or tarry stools, and vomit resembling coffee grounds.

• High Blood Pressure and Fluid Retention: This medication can cause fluid retention, contributing to elevated blood pressure and swelling, which may increase the risk of heart failure. Individuals with existing high blood pressure or heart failure should exercise caution.

• Kidney and Liver Concerns: Long-term use can result in kidney damage, especially in older adults or those with pre-existing kidney or liver conditions. Rarely, it may also cause elevated liver enzymes or liver failure.

• Severe Allergic Reactions: Life-threatening allergic reactions, including anaphylaxis, may occur. Celecoxib is contraindicated for individuals with known allergies to aspirin, other NSAIDs, or sulfa drugs. Seek immediate help if experiencing symptoms such as facial swelling or difficulty breathing.

• Pregnancy Warning: Using celecoxib during pregnancy, particularly after the 20th week, can harm the unborn baby, leading to serious complications. Pregnant individuals should discuss alternative treatments with their healthcare provider.

• Medication Overuse Headaches: Overuse of celecoxib for migraines can result in rebound headaches, where headache frequency increases.

Contraindications:

• History of asthma or allergic reactions to aspirin or NSAIDs
• Recent or planned heart surgery (CABG)
• Known allergy to celecoxib (Celebrex) or sulfonamides

Always consult with a healthcare professional to weigh the benefits and risks of celecoxib, particularly if any of the above warnings or contraindications apply to you.

When taking this medication, some individuals may experience a change in taste, which is generally mild and affects around 3% of users. If this persists or worsens, it is advisable to consult a healthcare provider. Anemia and high potassium levels have also been reported by some users. These effects should be discussed with a healthcare professional, especially if they become concerning.

More serious side effects, though rare, require immediate medical attention. These include symptoms of a stroke, such as blurred vision, difficulty speaking or walking, weakness on one side of the body, and severe headache. Signs of a heart attack, like chest pain or tightness radiating to the arm, neck, or jaw, difficulty breathing, and sweating, also necessitate urgent care. Heart failure symptoms, such as difficulty breathing, swelling, sudden weight gain, tiredness, and dizziness, should be addressed promptly.

Additionally, severe stomach or gut bleeding may manifest as blood in vomit or stools that resemble black coffee grounds, accompanied by persistent stomach pain. Serious allergic reactions or skin reactions, characterized by rash, hives, peeling skin, painful blisters, trouble breathing, and swelling of the face, mouth, or lips, require swift medical intervention. Signs of kidney problems, including changes in urination, tiredness, dry and itchy skin, low appetite, and muscle cramps, also warrant immediate attention.

This medication can increase blood pressure, so regular monitoring is recommended. If high readings are observed, consulting with a healthcare provider is important. While serious liver disease is very rare, symptoms such as persistent nausea or vomiting, loss of appetite, abdominal pain, yellowing of the eyes or skin, and dark urine should prompt immediate medical help. Always remain vigilant and seek medical advice if other unlisted side effects occur.

Some medications that can interact with this drug include Aliskiren, ACE inhibitors like Captopril and Lisinopril, angiotensin II receptor blockers such as Valsartan and Losartan, Cidofovir, Lithium, and diuretics like Furosemide. This drug may also elevate the risk of bleeding when taken with other medications that can cause bleeding. Such medications include anti-platelet drugs like Clopidogrel and blood thinners such as Dabigatran, Enoxaparin, and Warfarin.

It's important to review all prescription and over-the-counter medicine labels carefully, as many contain pain relievers or fever reducers like Aspirin, Naproxen, or Ibuprofen. These are similar to Celecoxib and could increase the likelihood of side effects if used together. However, if your doctor has recommended that you take low-dose aspirin (usually 81-162 milligrams a day) for heart attack or stroke prevention, you should continue unless advised otherwise by your doctor. For more information, consult your doctor or pharmacist.