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The following information provides essential safety and warning details for the use of Advair (fluticasone / salmeterol). It is crucial to understand these points and consult with your healthcare provider if you have any questions or concerns.

• Not for Immediate Relief: Advair should not be used to treat sudden breathing difficulties or asthma attacks. For immediate relief, a rescue inhaler such as albuterol (Ventolin HFA) should be used.

• Risk of Oral Fungal Infections: The steroid component in Advair can lead to thrush, a fungal infection in the mouth and throat, particularly if you do not rinse and spit after inhalation. Individuals with weakened immune systems are at higher risk. Symptoms include white patches, a cotton-like feeling, pain, and loss of taste. If you suspect thrush, inform your healthcare provider.

• Bronchospasm Risk: Inhaled medications like Advair can occasionally cause bronchospasms, leading to breathing difficulties, wheezing, and chest discomfort. If symptoms occur, use your rescue inhaler and seek medical help immediately.

• Increased Infection Risk: Corticosteroids in Advair may compromise your immune system, increasing the risk of infections such as pneumonia. If you have a severe infection, including tuberculosis, discuss alternative treatments with your provider. Report symptoms like fever and body aches promptly.

• Altered Hormone Levels: Overuse of Advair can lead to increased absorption of steroids, potentially causing elevated blood sugar or pressure. Follow prescribed dosages to avoid these risks.

• Effect on Child Growth: Inhaled steroids may affect growth in children. Healthcare providers will prescribe the minimal effective dose and monitor growth regularly.

• Eye Health Concerns: Long-term use of inhaled steroids has been linked to eye issues, including glaucoma and cataracts. Consult an eye specialist if you have these conditions or notice vision changes.

• Heart Considerations: Advair can influence blood pressure, heart rate, and rhythm, especially if overused. Regular monitoring is advised for those with heart conditions.

• Low Potassium Levels: Excessive use of Advair may lower blood potassium levels, causing symptoms like fatigue, muscle cramps, and tingling. Report these to your healthcare provider.

• Potential Allergic Reactions: Some individuals may experience severe allergic reactions, such as swelling or anaphylaxis. Seek urgent medical attention if symptoms such as hives or breathing difficulties occur.

Contraindications indicate situations where Advair should not be used, including:

• During a sudden, severe asthma attack.
• If allergic to fluticasone, salmeterol, or lactose/milk proteins.

Please ensure to discuss any of these conditions or symptoms with your healthcare provider to determine the best course of action for your treatment.

Common side effects:

• hoarseness
• throat irritation
• headaches
• stomach upset
• upper respiratory infections
• sore throat
• bronchitis
• cough
• nausea
• vomiting

Less common but important to monitor:

• high blood pressure
• persistent sore throat
• fever
• mental changes
• trouble sleeping
• vision problems
• increased thirst or urination
• muscle cramps
• tremors

Serious side effects:

• sudden worsening of breathing problems or asthma
• chest pain
• irregular heartbeat
• severe dizziness
• fainting
• seizures
• allergic reactions (rash, itching, swelling, difficulty breathing, severe dizziness)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Aldesleukin
• Desmopressin
• Azole antifungals such as ketoconazole
• Cobicistat
• Macrolide antibiotics such as clarithromycin
• HIV protease inhibitors such as lopinavir
• Nefazodone
• Ritonavir
• Telithromycin