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This safety information highlights crucial considerations when using this medication. Please read carefully and consult your healthcare provider with any questions or concerns.

• Risk of Overdose: Taking an excessive amount of folic acid by consuming more Foltrate (folic acid / cyanocobalamin) than prescribed, or combining it with other supplements or multivitamins that contain folic acid, can lead to serious side effects. Although adverse effects from excessive vitamin B12 are rare, it is crucial to adhere to your healthcare provider's dosing instructions for Foltrate. Since many over-the-counter products also contain these vitamins, it is advisable to consult your healthcare provider or pharmacist to avoid exceeding the recommended amounts. Be vigilant and inform your healthcare provider if you notice symptoms such as reduced appetite, nausea, bloating, unpleasant taste in the mouth, sleep disturbances, concentration difficulties, or irritability. The primary risk is taking more than the advised dosage.

No specific contraindications have been identified for this medication.

Foltrate is a prescription supplement that combines folic acid (vitamin B9) and cyanocobalamin (vitamin B12), essential nutrients for red blood cell production and overall health. While generally well-tolerated, some individuals may experience side effects. Common Side Effects:

• Gastrointestinal Issues: Some users may experience mild stomach upset, nausea, or vomiting. Serious Side Effects:
• Allergic Reactions: Although rare, severe allergic reactions can occur. Symptoms may include rash, itching, swelling, dizziness, or difficulty breathing. Immediate medical attention is necessary if these occur. Important Considerations:
• Vitamin B12 Deficiency Masking: High doses of folic acid can mask symptoms of vitamin B12 deficiency, potentially leading to nerve damage if left untreated.
• Drug Interactions: Folic acid may interact with certain medications, such as anticonvulsants and methotrexate, potentially reducing their effectiveness. Recommendations:
• Consult Healthcare Providers: Before starting Foltrate, discuss your medical history and current medications with your doctor to ensure it's appropriate for you.
• Monitor for Side Effects: Be vigilant for any adverse reactions. If you experience severe side effects or signs of an allergic reaction, seek medical attention promptly. Always follow your healthcare provider's instructions regarding dosage and duration of use to minimize potential risks.

Foltrate is a prescription supplement containing folic acid (vitamin B9) and cyanocobalamin (vitamin B12), essential nutrients for red blood cell production and DNA synthesis. While beneficial, Foltrate can interact with certain medications, potentially affecting their effectiveness or increasing the risk of side effects.

Major Interactions:

• Capecitabine: Combining Foltrate with capecitabine, a chemotherapy drug, may enhance capecitabine's effects, leading to serious side effects such as anemia, bleeding problems, infections, and nerve damage. Patients should be closely monitored for symptoms like severe nausea, vomiting, diarrhea, unusual bleeding or bruising, and numbness or tingling in the hands and feet.

Moderate Interactions:

• Maralixibat: This medication may decrease the absorption of fat-soluble vitamins, including those in Foltrate. Regular blood tests are recommended to ensure adequate vitamin levels and to determine if dosage adjustments are necessary.

• Sevelamer: Sevelamer can interfere with the absorption of vitamins A, D, E, and K. To minimize this interaction, it's advised to take Foltrate at least one hour before or four to six hours after sevelamer.

Other Notable Interactions:

• Anticonvulsants (e.g., Phenytoin, Phenobarbital): These medications may interfere with folate metabolism, potentially leading to decreased folate levels.

• Methotrexate: Used in cancer treatment and autoimmune diseases, methotrexate can affect folate metabolism.

• Cholestyramine: This cholesterol-lowering drug may interfere with the absorption of fat-soluble vitamins.

It's crucial to inform your healthcare provider about all medications, supplements, and over-the-counter products you're taking to avoid potential interactions. Do not start, stop, or change the dosage of any medication without consulting your doctor.