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Fondaparinux

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generic Arixtra

Fondaparinux is used to treat serious blood clots in the legs and/or lungs. It is usually used with another "blood thinner" medication (warfarin). If untreated, blood clots can travel to the lungs, heart, or brain, causing serious (possibly fatal) breathing problems, heart attack, or stroke. This drug may also be used to prevent blood clots after certain surgeries with an increased risk of blood clots (such as hip fracture, abdominal, knee/hip replacement). Fondaparinux is known as a "blood thinner" (anticoagulant). It is a drug similar to heparin that works by blocking certain natural substances in the blood that cause clotting.
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Fondaparinux WarningsFondaparinux Side EffectsInteractionsFAQs

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0.4ML of 5MG/0.4ML, Fondaparinux (1 Syringe)

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CVS

$28.44

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Walgreens

$20.66

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Albertsons

$41.65

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Rite Aid

$47.88

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Fondaparinux dosage forms

The average cost for 1 Syringe of Fondaparinux (generic Arixtra) at 0.5ML of 2.5MG/0.5ML is $7.36 with a free coupon. This is 3.38% off the average retail price of $217.88
DosageQuantityPrice fromPer unit
0.5ML of 2.5MG/0.5ML1 Syringe$7.36$7.36
0.4ML of 5MG/0.4ML1 Syringe$20.66$20.66
0.6ML of 7.5MG/0.6ML1 Syringe$28.76$28.76
0.8ML of 10MG/0.8ML1 Syringe$29.18$29.18

Fondaparinux Warnings

People using this medication may bleed near the spinal cord after certain spinal procedures. Bleeding in this area can cause paralysis that lasts a long time or could become permanent. Talk with your doctor about the benefits and risks before any spinal procedure. Your doctor may direct you to stop this medication for a certain amount of time before and after the procedure. Carefully follow your doctor's directions. The risk of bleeding may be higher if you have a deformed spine, or have had spinal procedures/surgery before (such as epidural catheter placement, difficult epidural/spinal puncture), or are taking other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, "blood thinners" such as warfarin/rivaroxaban, nonsteroidal anti-inflammatory drugs-NSAIDs such as ibuprofen). Tell your doctor right away if you notice symptoms such as back pain, leg numbness/tingling/weakness, loss of control of the bowels or bladder (incontinence).

Fondaparinux Side Effects

Pain, bruising, redness, and swelling at the injection site may occur. Headache, nausea, vomiting, swelling of the hands/feet, or fever may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: easy bleeding/bruising, dark urine, yellow eyes/skin. This medication may rarely cause serious bleeding. () Tell your doctor right away if you have any signs of serious bleeding, including: shortness of breath, coughing up blood, chest pain, cold/blue fingers or toes, unusual dizziness, fainting, fast/irregular heartbeat, joint/muscle pain, mental/mood changes (such as confusion), numbness/tingling, severe stomach/abdominal pain, bloody/black/tarry stools, red/pinkish urine, vomit that looks like coffee grounds. Get medical help right away if you have any very serious side effects, including: headache that is severe or doesn't go away, vision problems, weakness on one side of the body, trouble speaking, seizures, difficulty moving. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Interactions

Some products that may interact with this drug include: mifepristone, other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, NSAIDs such as ketorolac, "blood thinners" such as rivaroxaban). Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (NSAIDs such as ibuprofen, naproxen, aspirin) which can increase the risk of bleeding when used with fondaparinux. However, if your doctor has told you to take low-dose aspirin to prevent heart attack or stroke (usually 81-162 milligrams a day), you should keep taking the aspirin unless your doctor tells you not to. Ask your doctor or pharmacist for more details.
Fondaparinux FAQs
What drug is similar to Lovenox?

A drug similar to Lovenox (enoxaparin) is Fragmin (dalteparin). Both are low molecular weight heparins used to prevent and treat blood clots.

Fondaparinux is not the same as heparin. While both are anticoagulants used to prevent and treat blood clots, they differ in their chemical structure and mechanism of action. Fondaparinux is a synthetic pentasaccharide, whereas heparin is a naturally occurring polysaccharide. Additionally, fondaparinux specifically inhibits factor Xa, while heparin acts on multiple factors in the coagulation cascade.

Yes, fondaparinux is a factor Xa inhibitor. It works by selectively inhibiting factor Xa, which is an essential component in the coagulation cascade, thereby preventing blood clot formation.

Fondaparinux is an anticoagulant medication. It is specifically a synthetic pentasaccharide that works as a selective inhibitor of factor Xa, which helps prevent the formation of blood clots.

Low Molecular Weight Heparin (LMWH) and fondaparinux are both anticoagulants, but they differ in several ways:1. Structure: LMWH is derived from heparin and consists of smaller fragments, while fondaparinux is a synthetic pentasaccharide.2. Mechanism of Action: LMWH primarily inhibits factor Xa and has some effect on thrombin (factor IIa), whereas fondaparinux selectively inhibits factor Xa without affecting thrombin.3. Administration and Monitoring: Both are administered subcutaneously, but LMWH may require monitoring in certain populations, while fondaparinux typically does not require routine monitoring.4. Half-life: Fondaparinux has a longer half-life compared to LMWH, allowing for once-daily dosing.5. Reversal: LMWH effects can be partially reversed with protamine sulfate, whereas fondaparinux does not have a specific reversal agent.These differences influence their use in clinical practice, depending on the patient's specific needs and conditions.

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