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Before starting edoxaban, it's crucial to be aware of important safety information regarding its use. Below are key precautions and risks associated with this medication:

• Kidney Function: Edoxaban's effectiveness in preventing blood clots in patients with nonvalvular atrial fibrillation may be compromised if your kidneys function very efficiently (creatinine clearance greater than 95 mL/min). It’s essential to have your kidney function monitored regularly through blood tests as advised by your doctor.

• Risk of Blood Clots or Stroke: Do not discontinue edoxaban without your doctor's guidance. Stopping the medication prematurely may increase the risk of developing serious blood clots, such as a stroke or heart attack, especially in individuals with atrial fibrillation. Consult your healthcare provider if you are considering stopping or switching medications.

• Spinal Procedures: If you are undergoing spinal procedures, such as a spinal tap or epidural, edoxaban may increase the risk of bleeding around the spinal cord, potentially leading to long-term or permanent paralysis. Discuss the risks with your doctor before any spinal surgery or treatment, especially if you have a history of spinal issues or are using other medications that affect bleeding.

• Bleeding Risks: Edoxaban can cause severe and possibly life-threatening bleeding. While there are methods to reverse its effects, they may not be as straightforward as with other anticoagulants like warfarin. Always inform healthcare providers or emergency personnel that you are taking edoxaban, and consider wearing a medical alert bracelet for this purpose.

• Drug Interactions: Be cautious of drug interactions, particularly with nonsteroidal anti-inflammatory drugs (NSAIDs) and other blood thinners, as they can increase the risk of bleeding.

• Pregnancy and Other Conditions: If you are pregnant, have liver or kidney problems, or are at high risk of bleeding, consult your healthcare provider to evaluate the suitability of edoxaban for your condition.

In case of an overdose, seek immediate medical assistance. Always follow your healthcare provider's instructions and discuss any concerns or questions with them to ensure safe and effective use of edoxaban.

When taking this medication, some individuals may experience common side effects such as mild bleeding, changes in liver test results, or a rash. These side effects are generally not severe, but if they persist or worsen, it is advisable to consult a healthcare provider.

In rare instances, more serious side effects can occur, such as significant bleeding that requires immediate medical attention. This could manifest as frequent or unstoppable nosebleeds, unusual pain or swelling, heavy menstrual flow, pink or dark urine, coughing up blood, vomiting blood, severe headaches, dizziness, unusual tiredness, bloody stools, or difficulty swallowing.

Additionally, after procedures like an epidural or spinal tap, some may experience numbness, weakness, loss of bladder or bowel control, or tingling sensations in the back or legs. These symptoms are serious and necessitate urgent medical care.

A very serious allergic reaction, although rare, can also occur. If you notice symptoms such as a rash, itching, swelling—especially of the face, tongue, or throat—severe dizziness, or trouble breathing, seek immediate medical help.

If you experience any side effects not mentioned here, it is important to contact your healthcare provider for advice.