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Naproxen (Naprosyn) is a nonsteroidal anti-inflammatory drug (NSAID) that carries certain risks and precautions. Below is important safety information that should be reviewed before using this medication. If you have any questions or concerns, please discuss them with your healthcare provider.

• Heart Attack and Stroke Risk: Naproxen may increase the likelihood of blood clots, which could lead to a heart attack or stroke. This risk is heightened with prolonged use, higher doses, or existing heart conditions. It is not recommended for individuals who have had, or will undergo, heart surgery. Seek immediate medical help if you experience chest pain, shortness of breath, or difficulty speaking or walking.

• Stomach Bleeding: This medication may cause stomach ulcers and bleeding, potentially without prior symptoms. The risk is greater in older adults, those with a history of stomach issues, liver problems, or those consuming alcohol or smoking. Contact a healthcare professional immediately if you experience severe stomach pain, vomiting blood, or notice black or bloody stools.

• High Blood Pressure and Heart Failure: Naproxen can cause fluid retention, raising blood pressure or precipitating heart failure, especially in those with pre-existing heart conditions. Inform your healthcare provider if you have heart issues or are on blood pressure medication. Monitor for symptoms like chest pain during physical activity or irregular heartbeat.

• Kidney Damage: The medication may lead to kidney problems, particularly in older adults or those with diabetes or dehydration. Your healthcare provider may perform tests to monitor kidney function during treatment. Report any changes in urination, fatigue, or muscle cramps to your provider.

• Liver Problems: Although rare, naproxen can cause liver damage. Seek medical attention if you experience symptoms such as stomach swelling, jaundice, dark urine, or confusion.

• Severe Allergic Reactions: Allergic reactions, including anaphylaxis, are possible. If you have a known allergy to aspirin or other NSAIDs, inform your healthcare provider. If symptoms like hives, facial swelling, or breathing difficulties occur, seek emergency care.

• Pregnancy and Breastfeeding: Naproxen can harm an unborn baby, particularly if taken after the 20th week of pregnancy, and is not recommended during pregnancy or breastfeeding. Discuss potential risks and alternatives with your healthcare provider if you are pregnant or planning to become pregnant.

• Contraindications: Do not use naproxen if you have a history of asthma or allergic reactions to aspirin or other NSAIDs, or if you are scheduled for or have recently undergone coronary artery bypass graft surgery.

Always consult with your healthcare provider to understand the benefits and risks associated with the use of naproxen, and ensure it is safe for you, considering any existing health conditions or medications.

Common side effects:

• upset stomach
• heartburn
• nausea
• dizziness
• drowsiness
• headache
• itchy skin
• constipation
• stomach pain
• bruising

Less common but important to monitor:

• indigestion
• diarrhea
• mouth sores
• increased thirst
• sweating
• changes in hearing
• ringing in the ears

Serious side effects:

• stomach bleeding
• vomiting blood
• severe stomach pain
• heart attack
• stroke
• chest pain
• slurred speech
• heart failure
• difficulty breathing
• fast heartbeat
• high blood pressure symptoms
• worsening liver problems
• worsening kidney problems
• severe allergic reactions
• hives
• serious skin reactions
• blisters
• rashes

Interactions with high risk of serious adverse effects and should be avoided:

• Ketorolac

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Aliskiren
• ACE inhibitors (e.g., Captopril, Lisinopril)
• Angiotensin II receptor blockers (e.g., Losartan, Valsartan)
• Cidofovir
• Diuretics (e.g., Furosemide)
• Corticosteroids (e.g., Prednisone)
• Lithium
• Anti-platelet drugs (e.g., Clopidogrel)
• Anticoagulants (e.g., Dabigatran, Enoxaparin, Warfarin)
• NSAIDs (e.g., Celecoxib, Ibuprofen, ketorolac)