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Nonsteroidal anti-inflammatory drugs (NSAIDs), such as naproxen, carry a rare but serious risk of causing heart attacks or strokes. This risk can be present at any point during the use of the medication and is heightened with prolonged use. Individuals who are older or have existing heart conditions, or risk factors like smoking, family history of heart disease, high blood pressure, or diabetes, are at greater risk. It is advised not to use this medication immediately before or after undergoing heart bypass surgery (CABG).

In addition, naproxen may infrequently cause severe bleeding in the stomach or intestines, which can occur without any prior symptoms. The likelihood of this adverse effect is higher in older adults.

If you experience any of the following serious symptoms, stop taking naproxen and seek immediate medical assistance: persistent stomach or abdominal pain, black or tarry stools, vomit resembling coffee grounds, chest, jaw, or left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, difficulty speaking, or sudden visual changes.

Consult with your doctor or pharmacist to discuss both the advantages and risks associated with using this medication.

You might experience mild side effects such as an upset stomach, nausea, heartburn, headache, drowsiness, or dizziness. These are generally not serious and will often resolve on their own. However, if they persist or worsen, it's important to seek advice from a healthcare professional.

It's also possible for this medication to cause an increase in blood pressure. Regular monitoring of your blood pressure is recommended, and you should inform your healthcare provider if readings are high.

Some side effects can be more serious and require immediate attention. Contact your healthcare provider if you experience unusual bruising or bleeding, changes in hearing, mood alterations, signs of kidney issues (such as changes in urine output), vision changes, or symptoms indicating heart failure, such as swollen ankles, unusual tiredness, or sudden weight gain.

In rare instances, this drug may cause severe liver damage, which can be life-threatening. Seek urgent medical help if you notice persistent nausea or vomiting, loss of appetite, dark urine, stomach pain, or yellowing of the skin or eyes.

Although a serious allergic reaction is unlikely, it's crucial to get immediate medical assistance if symptoms such as fever, swollen lymph nodes, rash, severe dizziness, or breathing difficulties occur. If you notice any other effects, consulting with a healthcare professional is advisable.

Certain medications can interact with this drug. These include Aliskiren, ACE inhibitors like Captopril and Lisinopril, angiotensin II receptor blockers such as Losartan and Valsartan, Cidofovir, corticosteroids like Prednisone, Lithium, and diuretics (commonly known as "water pills") such as Furosemide. Taking this medication with others that increase bleeding risk, such as anti-platelet drugs like Clopidogrel or anticoagulants like Dabigatran, Enoxaparin, and Warfarin, may also increase the bleeding risk.

Be vigilant about checking labels on all your medications, both prescription and over-the-counter, as many contain pain relievers or fever reducers like Aspirin and NSAIDs (for instance, Celecoxib, Ibuprofen, or Ketorolac). These are similar to naproxen and could heighten the chances of side effects if used together. However, continue with low-dose aspirin (81-162 mg daily) for heart attack or stroke prevention if your doctor has advised it, unless otherwise directed. Note that regular naproxen use might reduce aspirin's effectiveness for heart protection. Discuss with your doctor the risks, benefits, and alternative treatments for pain or fever.

Additionally, this drug could affect some laboratory tests, leading to inaccurate results. Inform lab staff and all your healthcare providers that you are taking this medication.