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The following safety information and warnings outline the potential risks associated with the use of frovatriptan (Frova). It is crucial to read these carefully and discuss any concerns with your healthcare provider.

• Heart-Related Risks: There are rare instances of serious heart issues occurring shortly after taking frovatriptan, including heart attacks and chest pain (angina). These can affect both those with and without a history of heart disease. Factors that increase this risk include older age, personal or family history of coronary artery disease, diabetes, high blood pressure, smoking, and obesity.

• Irregular Heartbeat: Life-threatening arrhythmias have been reported within hours of taking frovatriptan. Do not use this medication if you have a medical condition that causes arrhythmia. Seek immediate medical attention if you experience symptoms such as a slow heartbeat, pounding or fluttering heart, chest pain, dizziness, weakness, or difficulty breathing.

• Stroke and Brain Injuries: Some users of frovatriptan have suffered from strokes or brain hemorrhages. Do not take frovatriptan if you have a history of stroke, transient ischemic attacks, hemiplegic migraine, or basilar migraine, as these conditions already elevate your stroke risk.

• Blood Vessel Narrowing: Frovatriptan may cause extreme narrowing of blood vessels, potentially restricting blood flow and causing complications.

• Rebound Headaches: Overuse of frovatriptan or exceeding the recommended dosage can lead to medication-overuse headaches, where migraine-like symptoms become more frequent.

• Serotonin Syndrome: The use of frovatriptan can increase the risk of serotonin syndrome, a serious condition resulting from elevated serotonin levels in the brain. This risk is heightened when taken with other medications that elevate serotonin, such as antidepressants.

• High Blood Pressure: There are rare cases of significant increases in blood pressure after taking frovatriptan, which can be dangerous. This can occur in individuals with or without a prior history of high blood pressure. Avoid this medication if you have uncontrolled high blood pressure.

• Allergic Reactions: Frovatriptan can cause life-threatening allergic reactions, including anaphylaxis and facial swelling. Discontinue use and call emergency services immediately if you experience symptoms like a rash, swelling of the face, mouth, or throat, throat closure, or difficulty breathing.

Contraindications: Avoid using frovatriptan if you have any of the following conditions or risk factors, as they may pose significant health risks:

• Coronary artery disease (CAD) or coronary artery vasospasm (e.g., Prinzmetal's angina)
• Conditions leading to irregular heart rhythms, such as Wolff-Parkinson-White syndrome
• History of stroke or transient ischemic attack
• History of hemiplegic or basilar migraine
• Uncontrolled high blood pressure
• Peripheral vascular disease
• Ischemic bowel disease
• Recent use (within 24 hours) of ergot-containing medications or other triptans

It's essential to adhere to these guidelines to ensure safe and effective use of frovatriptan. Always consult your healthcare provider if you have any questions or concerns.

When using this medication, you may experience some common side effects that are typically mild and manageable. These include dizziness, tiredness, headaches, a "pins and needles" feeling in the hands or legs, flushing, dry mouth, and sensations of heat or cold. Occasionally, you might also notice bone pain, indigestion, chest pain, or a general feeling of discomfort. If these effects persist or worsen, it's important to consult your healthcare provider.

There are other side effects that have been reported, which may vary in severity. These can include a painful or burning sensation, stomach pain, diarrhea, vomiting, anxiety, trouble sleeping, increased sweating, ringing in the ears, changes in vision, and a racing heart. While these are less common, you should reach out to your healthcare provider if they occur.

Rarely, some serious side effects may occur that require immediate medical attention. These include symptoms of a heart attack, such as severe chest pain that can spread to the arms, neck, or jaw, accompanied by shortness of breath, sweating, or nausea. An irregular heart rhythm, characterized by a slow or fluttering heartbeat, chest pain, or dizziness, also necessitates urgent care. Signs of a stroke, like sudden weakness on one side of the body, severe headache, or changes in speech or vision, are critical and need immediate intervention.

Additionally, this medication can lead to extremely high blood pressure, presenting as a severe headache, confusion, chest pain, or trouble breathing. Serotonin syndrome, a very serious condition marked by fever, rapid heartbeat, and movement problems, requires prompt medical help. Lastly, a serious allergic reaction, identifiable by symptoms such as trouble breathing, rash, or swelling of the face, mouth, or throat, demands immediate attention. Always consult your healthcare provider if you notice any unusual effects.

When taking Frovatriptan, be aware of potential drug interactions that could increase the risk of serious side effects. One such interaction involves medications that elevate serotonin levels, which could lead to serotonin syndrome—a potentially life-threatening condition. Drugs that can increase serotonin include certain antidepressants like SSRIs (such as Fluoxetine and paroxetine), SNRIs (such as Duloxetine and Venlafaxine), street drugs like MDMA, and herbal supplements like St. John's Wort. This risk is heightened when starting or increasing doses of these drugs.

Additionally, if you are using ergotamine-based medications (such as Dihydroergotamine) or other triptans (such as Zolmitriptan and Rizatriptan), it is crucial to space out your Frovatriptan dosage by at least 24 hours from these medicines to minimize adverse effects.

Consult your healthcare provider about all the medications and supplements you are taking, including over-the-counter drugs and herbal products, to ensure safe use of Frovatriptan. Your doctor may need to adjust your medication regimen to avoid potential interactions.