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This medication has specific safety warnings and contraindications that are essential for ensuring patient safety. Please read the following information carefully and discuss any concerns with your healthcare provider.

• Cardiovascular Risks: Eletriptan (Relpax) may cause serious cardiovascular events, such as heart attacks and heart rhythm disturbances, shortly after use. It can also increase blood pressure significantly. The risk is higher in individuals with a history of heart problems, those over 65 years old, individuals with obesity, diabetes, high blood pressure, or those who smoke.

• Neurological Concerns: There is a risk of stroke or brain bleeding in patients using triptans like eletriptan. Those with a history of stroke should not use this medication. Always inform your healthcare provider about your medical history.

• Vascular Effects: Eletriptan can cause significant narrowing of blood vessels, leading to severe stomach issues, vision disturbances, or sensory changes in extremities. Symptoms may mimic Raynaud's phenomenon, such as color changes in hands and feet. Discontinue use and consult your healthcare provider if these symptoms occur.

• Medication Overuse Headaches: Overusing eletriptan or other migraine medications can lead to increased frequency of headaches or diminished effectiveness. If you find yourself needing to take these medications more than 9 days a month or experience more than 3 migraines a month, consult your healthcare provider for alternative treatments.

• Serotonin Syndrome Risk: A rare but potentially fatal condition, serotonin syndrome, may occur, especially if used with other serotonin-enhancing medications.

Contraindications include:

• Coronary Issues: Avoid use if you have coronary artery disease, a history of heart attack, or coronary artery vasospasm (e.g., Prinzmetal's angina).

• Heart Rhythm Disorders: Conditions like Wolff-Parkinson-White syndrome or arrhythmias are contraindications.

• Previous Strokes: A history of stroke or mini-stroke disqualifies use.

• Specific Migraine Types: Do not use for hemiplegic or basilar migraines.

• Uncontrolled Hypertension: Avoid use if you have uncontrolled high blood pressure.

• Other Vascular Diseases: Conditions like peripheral vascular disease or ischemic bowel disease are contraindications.

• Drug Interactions: Do not use if you have taken ergot derivatives or other triptans in the past 24 hours, or certain medications like ketoconazole, itraconazole, clarithromycin, nefazodone, ritonavir, or nelfinavir within the last 72 hours.

In the event of an overdose, seek immediate medical assistance. Adhering to these guidelines is crucial to minimize risks and ensure effective treatment.

When taking this medication, some individuals may experience mild side effects such as dizziness, sleepiness, nausea, weakness, or a tingling sensation in the limbs. These effects are generally not serious but should be discussed with a healthcare provider if they persist or worsen. Other common symptoms include headache, dry mouth, flushing, heartburn, and stomach pain. Some may feel tightness or discomfort in the chest or throat, which, while usually not severe, should still be monitored.

On a more serious note, this medication can cause significant side effects, albeit rarely. These include cardiovascular issues like heart attack symptoms—chest pain, trouble breathing, or irregular heartbeat—and extremely high blood pressure, which may manifest as severe headache or confusion. Stroke symptoms such as sudden weakness, speech or vision changes, and confusion also warrant immediate medical attention. Additionally, some users might experience a narrowing of blood vessels, leading to severe stomach pain, bloody diarrhea, or vision problems.

A rare but serious condition known as serotonin syndrome may occur, especially if combined with other serotonin-increasing drugs. Symptoms include a rapid heart rate, hallucinations, severe dizziness, and muscle twitching. An allergic reaction to this medication is uncommon but serious, with symptoms like rash, swelling of the face or throat, and difficulty breathing. Immediate medical help is essential if any of these severe side effects occur. Always report any unusual or severe symptoms to your healthcare provider promptly.

When taking Eletriptan (Relpax), it's important to be aware of potential interactions with other medications. Certain drugs can interfere with how Eletriptan is processed in your body if taken within 72 hours. These include cobicistat, nefazodone, ribociclib, ritonavir, azole antifungals like ketoconazole and itraconazole, macrolide antibiotics such as clarithromycin and erythromycin, and HIV protease inhibitors like nelfinavir. Additionally, if you are on ergotamine medications (e.g., dihydroergotamine) or other triptan medications (e.g., sumatriptan, rizatriptan), make sure to space out your doses of Eletriptan and these drugs by at least 24 hours to minimize the risk of serious side effects.

There is also a heightened risk of developing serotonin syndrome, a potentially life-threatening condition, when Eletriptan is combined with drugs that increase serotonin levels. This risk is particularly significant when you start or increase the dosage of such drugs. Examples include MDMA ("ecstasy"), St. John's wort, and certain antidepressants like SSRIs (e.g., fluoxetine, paroxetine) and SNRIs (e.g., duloxetine, venlafaxine).

Always inform your healthcare provider about all the medications and supplements you are taking, including prescription, over-the-counter, and herbal products, to ensure safe and effective use of Eletriptan.