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This medication combines two hormones: an estrogen (like conjugated estrogen or estradiol) and a progestin (such as medroxyprogesterone, norethindrone, or norgestimate). Some variations may include progesterone instead of a progestin. Both progesterone and progestin mimic the natural hormone produced by the body. It is primarily used by women to alleviate menopause symptoms such as hot flashes and vaginal dryness, which occur due to decreased estrogen levels. The inclusion of progestin or progesterone helps lower the risk of uterine cancer associated with estrogen use. Women who have had a hysterectomy do not require progestin or progesterone and should not use this combination therapy. If treating only vaginal symptoms, topical applications are recommended over oral, transdermal, or injectable forms. Additionally, this medication can be used to prevent osteoporosis after menopause. However, other treatments like raloxifene or bisphosphonates (e.g., alendronate) may offer safer alternatives and should be considered first.