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Nonsteroidal anti-inflammatory drugs, such as ibuprofen, have been associated with a slight risk of heart attack or stroke. This risk can develop at any point during use but is more pronounced with prolonged use. The likelihood of these events may be higher in older individuals or those with pre-existing heart conditions or risk factors, including smoking, a family history of heart disease, high blood pressure, or diabetes. It is important to avoid using this medication immediately before or after undergoing heart bypass surgery (CABG).

Additionally, ibuprofen may infrequently lead to severe, potentially fatal, bleeding in the stomach or intestines, which can occur without prior symptoms. The risk of this side effect is increased in older adults.

If you experience any rare but serious symptoms, such as persistent stomach or abdominal pain, black or tarry stools, vomit resembling coffee grounds, chest, jaw, or left arm pain, difficulty breathing, unusual sweating, confusion, weakness on one side of the body, trouble speaking, or sudden vision changes, discontinue use and seek medical attention immediately.

It is crucial to discuss with your healthcare provider or pharmacist the potential benefits and risks associated with the use of this medication.

You might experience some mild side effects such as an upset stomach, nausea, vomiting, headache, diarrhea, constipation, dizziness, or drowsiness. These are generally manageable, but if they persist or worsen, consult with your healthcare provider.

It's important to monitor your blood pressure as this medication can cause an increase. If you notice elevated readings, inform your healthcare provider.

Be aware of more serious side effects, which require immediate medical attention. These include easy bruising or bleeding, changes in hearing like ringing in the ears, mental or mood changes, an unexplained stiff neck, signs of kidney problems such as a change in urine output, vision changes, and symptoms of heart failure like swelling in the ankles or feet, unusual tiredness, or sudden weight gain.

Rarely, this medication can cause serious liver issues. Seek urgent medical help if you experience persistent nausea or vomiting, loss of appetite, dark urine, stomach or abdominal pain, or yellowing of the eyes or skin.

Though uncommon, a severe allergic reaction can occur. If you notice symptoms such as fever, swollen lymph nodes, rash, itching or swelling, particularly of the face, tongue, or throat, severe dizziness, or trouble breathing, get medical help immediately.

These are not all the possible side effects. If you experience any other unusual symptoms, reach out to your healthcare provider for guidance.

Certain drugs can interact with this medication. These include aliskiren, ACE inhibitors like captopril and lisinopril, angiotensin II receptor blockers such as losartan and valsartan, cidofovir, corticosteroids like prednisone, lithium, and diuretics like furosemide. Combining this medication with others that increase bleeding risk can be dangerous. This includes anti-platelet medications like clopidogrel and blood thinners such as dabigatran, enoxaparin, and warfarin.

Carefully check both prescription and over-the-counter medications, as many contain pain relievers or fever reducers similar to ibuprofen, like aspirin and NSAIDs such as celecoxib, ketorolac, or naproxen. Taking these with this medication could increase side effects. If your doctor has recommended low-dose aspirin (81-162 milligrams daily) to prevent heart attack or stroke, continue taking it unless advised otherwise. However, ibuprofen might reduce aspirin’s effectiveness in preventing such conditions. Discuss alternative pain relievers like acetaminophen with your doctor. If ibuprofen is necessary, consult your doctor about taking immediate-release aspirin (not enteric-coated) alongside it, and ensure there is at least an 8-hour gap before or a 2-hour gap after taking ibuprofen. Never change your aspirin or other medication doses without consulting your doctor.