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Humatin (paromomycin) is a medication that requires careful consideration of its safety information to minimize potential risks. Please review the following points and consult your healthcare provider if you have any concerns:

• Risk of New Infections: Humatin (paromomycin) may not eliminate all bacteria and germs, which can allow surviving pathogens to multiply and potentially cause a new infection. If you develop a new fever, experience worsening symptoms, or do not feel better after completing your treatment, contact your healthcare provider promptly.

• Kidney Injury in Intestinal Ulcer Patients: Normally, Humatin (paromomycin) is not absorbed into the body as it passes through the intestines. However, if you have ulcers in your large intestines, some medication may be absorbed, leading to potential kidney injury. Inform your prescriber of any conditions related to intestinal ulcers before starting this medication.

• Contraindications: Do not use Humatin (paromomycin) if you have a blockage in the intestine, as it could result in serious health risks. Discuss any such conditions with your healthcare provider before taking this medication.

Adhere to these guidelines to use Humatin (paromomycin) safely and effectively.

When taking Humatin (paromomycin), it's important to be aware of potential interactions with other medications and health conditions:

Drug Interactions:

• Other Aminoglycosides: Combining Humatin with other aminoglycoside antibiotics can increase the risk of kidney and ear toxicity. It's advisable to avoid such combinations unless specifically directed by a healthcare provider.

• Diuretics: Certain diuretics, like Furosemide, may enhance the toxic effects of Humatin on the kidneys and ears. Caution is recommended when these are used together.

• Neuromuscular Blocking Agents: Humatin can intensify the effects of medications that relax muscles during surgery, such as succinylcholine, potentially leading to prolonged muscle relaxation.

• Proton Pump Inhibitors (PPIs): Long-term use of PPIs like Lansoprazole with Humatin may lower magnesium levels in the blood, which can cause symptoms like irregular heartbeats and muscle spasms. Monitoring magnesium levels is advisable in such cases.

• Probiotics: Taking probiotics alongside Humatin might reduce the effectiveness of the probiotics. To minimize this interaction, consider taking them at least two hours apart.

• Activated Charcoal: Using activated charcoal with Humatin can decrease the absorption of the antibiotic, potentially reducing its effectiveness. It's best to avoid this combination unless under medical supervision.

Disease Interactions:

• Intestinal Obstruction: Humatin is not recommended for individuals with intestinal blockages, as it may be absorbed into the bloodstream in higher amounts, increasing the risk of side effects.

• Gastrointestinal Inflammation: Conditions like colitis or ulcers can lead to increased absorption of Humatin, raising the potential for toxicity. Caution is advised when prescribing Humatin to patients with these conditions.

Always inform your healthcare provider about all medications, supplements, and health conditions before starting Humatin to ensure safe and effective treatment.