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This medication comes with several important safety warnings and precautions. Please read through this information carefully and consult your healthcare provider if you have any questions or concerns.

• Liver Damage: Erythromycin can potentially cause severe or life-threatening liver damage, especially if you have a history of liver problems. Be alert for symptoms such as unexplained stomach pain, nausea, vomiting, dark urine, pale stools, or yellowing of the skin or eyes, and contact your healthcare provider immediately if these occur. Regular blood tests are recommended to monitor liver function.

• Heart Rhythm Changes (QT Prolongation): In rare cases, erythromycin may cause a serious heart rhythm problem known as QT prolongation, which could be fatal. This risk is heightened in individuals with certain heart conditions or those over 65. Avoid taking erythromycin with other medications that also cause QT prolongation. Inform your healthcare provider about any heart conditions and provide a comprehensive list of all medications and supplements you are taking.

• Syphilis in Infants: Erythromycin may not fully prevent syphilis transmission from mother to baby during pregnancy, as it might not reach the baby effectively. If you were treated with erythromycin for syphilis during pregnancy, inform your healthcare provider; your baby will require antibiotics after birth.

• Severe Diarrhea (C. difficile): Erythromycin may increase the risk of Clostridioides difficile-associated diarrhea (CDAD), a potentially life-threatening condition. Stop taking erythromycin and seek medical attention if you experience bloody or watery stools. This risk is higher in individuals over 65, those with weakened immune systems, recent hospital stays, or prolonged antibiotic use.

• Drug Interactions: Erythromycin interacts with many medications, some of which can be dangerous. Consult your healthcare provider about all medications you are taking to avoid potential heart rhythm complications.

• Myasthenia Gravis: Erythromycin can exacerbate symptoms of myasthenia gravis, such as muscle weakness and breathing difficulties. Discuss any concerns with your healthcare provider if you have this condition.

• Intestinal Blockage in Infants: Erythromycin can cause a blockage between the stomach and small intestine in infants, especially with prolonged use. It is generally not recommended for infants unless necessary for life-threatening conditions. Watch for symptoms like vomiting or fussiness while eating and contact your child's healthcare provider immediately if they occur.

Contraindications: This medication should not be used if you are taking terfenadine, astemizole, pimozide, cisapride, ergotamine, dihydroergotamine, lovastatin, or simvastatin (Zocor). Consult your healthcare provider if you are on any of these medications.

When taking this medication, some common side effects you might experience include nausea, vomiting, stomach pain, diarrhea, and anorexia. These are generally mild and often resolve on their own, but if they persist or become bothersome, it's advisable to consult a healthcare professional for guidance.

There are other side effects that have been reported, such as rash, hives, and hearing loss. While these are less common, it is important to monitor your condition and seek medical advice if they occur, especially if they become severe.

More serious side effects, although rare, demand immediate medical attention. These include liver damage, which may present with symptoms like fever, chills, fatigue, yellowing of the skin or eyes, and dark urine. An abnormal heart rhythm, signaled by a pounding heartbeat or dizziness, also requires urgent care. Clostridioides difficile-associated diarrhea can be identified by watery or bloody diarrhea, stomach pain, and fever. Lastly, a severe allergic or skin reaction may manifest with symptoms like fever, rash, body aches, and blisters. Prompt medical evaluation is crucial if you experience any of these serious symptoms.