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This document outlines critical safety information regarding potential risks associated with the use of hyoscyamine. It is essential to review these warnings carefully and discuss any concerns with your healthcare provider.

• Dizziness and Drowsiness: Hyoscyamine may induce sleepiness, dizziness, or blurred vision. Avoid driving or engaging in tasks that require full attention until you understand how the medication affects you.

• Mood and Cognitive Changes: The medication can affect mood and cognitive functions, potentially causing confusion, memory loss, or disorientation. Symptoms such as agitation, hallucinations, or euphoria may occur, and in severe instances, it can lead to a coma. These effects typically resolve within 12 to 48 hours after stopping the medication. Promptly inform your healthcare provider if you notice any mood or cognitive changes. Individuals aged 65 or older and those with mental health conditions are at increased risk.

• Increased Heart Rate: Hyoscyamine may elevate heart rate, which could exacerbate existing heart conditions like heart failure, history of heart attacks, or hypertension. Monitor for changes in heart rate or symptoms like a pounding or racing heart, and inform your provider if these occur. Those with heart problems or high blood pressure should exercise caution.

• Autonomic Function Alterations: The medication may alter involuntary bodily functions, leading to issues such as slowed gut muscles resulting in constipation, reduced saliva or sweat production causing dry mouth and increased thirst, and a higher risk of heat stroke. It can also affect heart rate and vision. Report any changes in bodily functions to your healthcare provider and avoid taking hyoscyamine if you have a fever without consulting your provider first. There is heightened risk for individuals aged 65 or older.

• Urination Difficulties: Use hyoscyamine cautiously if you have prostate issues, as it may worsen urination difficulties.

• Caution with Specific Gastrointestinal Conditions: If you have undergone a colostomy or similar procedures, consult your provider before using hyoscyamine for diarrhea, as it may indicate a blockage in the gut and could be harmful.

Contraindications: Hyoscyamine should not be used if you have any of the following conditions due to the risk of severe health complications:

• Glaucoma
• Urinary tract blockage
• Gastrointestinal blockage
• Chronic constipation
• Unstable heart or bleeding disorders
• Severe ulcerative colitis with toxic megacolon
• Myasthenia gravis

If any of these conditions apply to you, seek advice from your healthcare provider before using this medication.

When taking this medication, you might experience some common side effects, which are generally mild. These include dizziness, drowsiness, blurred vision, dry mouth, headache, trouble sleeping, constipation, flushing, dry skin, and decreased sweating. If these symptoms persist or worsen, it's advisable to consult with your healthcare provider. To manage dry mouth, consider using sugarless candy, ice chips, or gum, drinking water, or using a saliva substitute.

In some instances, you may encounter other side effects such as trouble urinating, dry eyes, and head intolerance. While these can be bothersome, they are not typically severe. However, if you notice symptoms like a fast or irregular heartbeat, diarrhea, confusion, or short-term memory loss, it's important to discuss these with your doctor.

Serious side effects are rare but require immediate medical attention. Watch out for severe mood changes, such as confusion, unusual excitement, or psychosis, as well as any changes in your heartbeat, including fainting, dizziness, chest discomfort, or difficulty breathing. Vision changes, including seeing rainbows around lights at night, or experiencing eye pain, swelling, or redness, also warrant urgent care.

Although a serious allergic reaction is uncommon, seek medical help immediately if you notice a rash, severe dizziness, trouble breathing, or swelling, particularly of the face, tongue, or throat. Always consult your healthcare provider if you experience any new or unexpected symptoms.

When taking this medication, it's important to be aware of potential interactions with other drugs. This includes specific antifungal medications like Ketoconazole and Itraconazole, bisphosphonates such as Alendronate and Risedronate, corticosteroids like Prednisone, and certain forms of Digoxin. Additionally, potassium supplements and pramlintide may interact with this drug.

Inform your healthcare provider if you're using other substances that may induce drowsiness, such as opioid pain relievers (e.g., codeine, hydrocodone), alcohol, cannabis, sleep aids (e.g., Zolpidem), anxiety medications (e.g., Alprazolam, Lorazepam), muscle relaxants (e.g., Carisoprodol, Cyclobenzaprine), or antihistamines (e.g., Cetirizine, diphenhydramine).

Be sure to check all your medications, including over-the-counter products, for ingredients that can cause drowsiness, and consult your pharmacist for safe usage. This medication may also interfere with certain laboratory tests, potentially leading to false results, so ensure all your healthcare providers are aware of your medication use.

Hyoscyamine, the active ingredient, can also have significant interactions with a wide range of other medications, including but not limited to ambenonium, bepridil, and various other drugs listed. It is crucial to discuss all medications you are taking with your healthcare provider to avoid any adverse effects or drug interactions.