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This safety information outlines important precautions and potential risks when using imiquimod. Please review these warnings carefully and discuss any concerns with your healthcare provider.

• Skin Inflammation: Imiquimod may cause severe skin irritation. Ensure any previously treated or surgical areas are fully healed before starting this medication. Contact your healthcare provider immediately if you experience blisters, weeping, severe peeling, or difficulty urinating due to genital swelling. You may need to halt use until symptoms resolve.

• Flu-like Symptoms: Users may experience symptoms similar to the flu, such as fever, nausea, muscle aches, chills, or swollen lymph nodes. Notify your provider promptly, as discontinuation might be necessary until recovery.

• Sun Sensitivity: Imiquimod increases skin sensitivity to sunlight and UV light. Avoid sun exposure and tanning; use sunscreen and protective clothing if exposure is unavoidable. Do not apply the cream to sunburned skin until fully healed. Consult your provider if your lifestyle necessitates prolonged sun exposure.

• Actinic Keratosis Caution (Aldara only): Limited information is available on using imiquimod for multiple treatment cycles on the same actinic keratosis area. Consult your provider if the initial treatment was ineffective or symptoms recur. Avoid using on large areas (exceeding 5 cm x 5 cm) without medical advice.

• Not for Other Skin Cancers (Aldara only): Imiquimod is approved only for treating basal cell carcinoma on specific body parts, such as the torso, neck, and arms (excluding hands). It is not suitable for more severe skin cancers or those on the face, head, or genitals. Regular follow-ups with your provider are crucial.

• Not for HPV Treatment (Aldara only): Imiquimod does not cure human papilloma virus (HPV), and new warts may appear and remain contagious. Discuss any questions regarding HPV with your provider.

• Avoid Concurrent Imiquimod Products (Zyclara only): Using multiple imiquimod-containing products simultaneously can heighten side effects. Confirm with your provider before combining treatments.

• Autoimmune Disease Caution (Zyclara only): Imiquimod activates immune responses. If you have an autoimmune condition, consult your healthcare provider before use, as it may exacerbate your condition.

If you experience an overdose, seek immediate medical attention. Always follow your healthcare provider's instructions and report any adverse effects promptly.

When using this medication, some individuals may experience common side effects, which are generally mild and include skin reactions such as itching, burning, stinging, or pain, as well as symptoms resembling a common cold, like a runny or stuffy nose, and sinus inflammation. Other frequent side effects are headaches, diarrhea, nausea, and back pain. These reactions are usually manageable but should be discussed with a healthcare provider if they persist or worsen.

In some cases, users have reported additional side effects such as eczema, hair loss, dizziness, fatigue, fever, chills, vomiting, and viral infections. There is also a possibility of experiencing more serious conditions like skin cancer, atrial fibrillation, or urinary tract infections. If any of these occur, it is important to contact a healthcare professional for further guidance.

Rare but severe side effects require immediate medical attention. These include severe skin reactions characterized by bleeding, sores, blisters, or ulcers, as well as difficulty urinating due to genital swelling. Additionally, any signs of a serious allergic reaction, such as rash, significant swelling, severe dizziness, or trouble breathing, necessitate urgent medical care.

While the risk of these severe side effects is low, monitoring your body's response to the medication is crucial. If any new or unusual symptoms arise, consulting with a healthcare provider can ensure your safety and well-being while using this medication.