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This safety information outlines important precautions and potential risks when using imiquimod. Please review these warnings carefully and discuss any concerns with your healthcare provider.

• Skin Inflammation: Imiquimod may cause severe skin irritation. Ensure any previously treated or surgical areas are fully healed before starting this medication. Contact your healthcare provider immediately if you experience blisters, weeping, severe peeling, or difficulty urinating due to genital swelling. You may need to halt use until symptoms resolve.

• Flu-like Symptoms: Users may experience symptoms similar to the flu, such as fever, nausea, muscle aches, chills, or swollen lymph nodes. Notify your provider promptly, as discontinuation might be necessary until recovery.

• Sun Sensitivity: Imiquimod increases skin sensitivity to sunlight and UV light. Avoid sun exposure and tanning; use sunscreen and protective clothing if exposure is unavoidable. Do not apply the cream to sunburned skin until fully healed. Consult your provider if your lifestyle necessitates prolonged sun exposure.

• Actinic Keratosis Caution (Aldara only): Limited information is available on using imiquimod for multiple treatment cycles on the same actinic keratosis area. Consult your provider if the initial treatment was ineffective or symptoms recur. Avoid using on large areas (exceeding 5 cm x 5 cm) without medical advice.

• Not for Other Skin Cancers (Aldara only): Imiquimod is approved only for treating basal cell carcinoma on specific body parts, such as the torso, neck, and arms (excluding hands). It is not suitable for more severe skin cancers or those on the face, head, or genitals. Regular follow-ups with your provider are crucial.

• Not for HPV Treatment (Aldara only): Imiquimod does not cure human papilloma virus (HPV), and new warts may appear and remain contagious. Discuss any questions regarding HPV with your provider.

• Avoid Concurrent Imiquimod Products (Zyclara only): Using multiple imiquimod-containing products simultaneously can heighten side effects. Confirm with your provider before combining treatments.

• Autoimmune Disease Caution (Zyclara only): Imiquimod activates immune responses. If you have an autoimmune condition, consult your healthcare provider before use, as it may exacerbate your condition.

If you experience an overdose, seek immediate medical attention. Always follow your healthcare provider's instructions and report any adverse effects promptly.

When using Aldara (imiquimod), it's important to be aware of potential interactions with other medications, especially those that can increase your skin's sensitivity to light, a condition known as photosensitivity. Combining Aldara with certain drugs may heighten the risk of severe sunburn or skin reactions upon exposure to sunlight or bright indoor lights. Notable medications that can interact with Aldara in this way include:

• Methoxsalen: This medication makes your skin more sensitive to sunlight. Using it alongside Aldara may increase the likelihood of severe sunburn. It's advisable to consult your doctor about whether to pause any medications before and after methoxsalen treatment. After using methoxsalen, avoid sunlight or artificial UV rays for at least 24 hours. If sun exposure is unavoidable, wear protective clothing and use a sunscreen with SPF 15 or higher.

• Porfimer: This drug can cause your skin to react more strongly to light. Combining it with Aldara may lead to increased photosensitivity reactions, such as redness, swelling, itching, or burning sensations. It's recommended to avoid using Aldara for at least 30 days after porfimer therapy and until tests confirm no residual photosensitivity.

• Verteporfin: This medication also increases skin sensitivity to light. Using it with Aldara may elevate the risk of photosensitivity reactions. After verteporfin treatment, avoid exposing your skin or eyes to sunlight or bright indoor lights for 5 days. If you must go outdoors during this period, protect your skin and eyes by wearing protective clothing and dark sunglasses.

• Aminolevulinic Acid: This substance sensitizes your skin to bright lights. Combining it with Aldara may raise the risk of severe sunburn. Generally, it's recommended to avoid other photosensitizing medications for 24 hours before and after taking aminolevulinic acid. After treatment, avoid exposure to sunlight or bright indoor lights for 48 hours.

Additionally, be cautious when using Aldara with other topical medications or products that may irritate the skin. Always inform your healthcare provider about all medications, supplements, and herbal products you are currently using. They can provide guidance on whether any adjustments are necessary to ensure your safety while using Aldara.