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When taking Jatenzo (testosterone undecanoate), it is important to be aware of the potential risks and necessary precautions to ensure safe use. Below are essential safety warnings and instructions for users:

• Increased Blood Pressure and Heart Risk: This medication may elevate your blood pressure, heightening the risk of severe heart issues, including heart attacks and strokes. This risk is more pronounced in individuals with pre-existing heart conditions or other risk factors. Regular blood pressure monitoring is advised. Consult your healthcare provider immediately if you experience symptoms of heart problems.

• Elevated Red Blood Cell Count: Jatenzo can increase red blood cell levels, potentially leading to blood clots, heart attacks, or strokes. Regular blood tests every three months are recommended to monitor these levels. Adjustments in dosage or a temporary halt in treatment may be necessary if levels are too high.

• Blood Clots: The medication can cause serious blood clots in the legs or lungs. Be vigilant for symptoms like leg pain, swelling, redness, trouble breathing, or chest pain. Seek immediate medical attention if these occur.

• Misuse and Dependency: As a controlled substance, Jatenzo presents a risk of misuse, dependency, and addiction, particularly if used in higher-than-prescribed doses or in conjunction with other testosterone products.

• Prostate Health: Jatenzo may worsen symptoms in individuals with an enlarged prostate (BPH) and could increase the risk of prostate cancer. Report any urinary changes to your healthcare provider.

• Liver Concerns: Although not specifically associated with Jatenzo, long-term use of some testosterone forms can cause liver issues. Monitor for signs like abdominal pain, jaundice, or dark urine and inform your prescriber if they occur.

• Sperm Production: High doses of testosterone can impact sperm production, affecting fertility. Discuss potential effects on fertility with your healthcare provider if planning to have children.

• Fluid Retention (Edema): The medication can cause your body to retain salt and water, leading to swelling in the limbs, especially if you have heart, liver, or kidney issues. Contact your prescriber if swelling occurs.

• Sleep Apnea: Jatenzo can exacerbate sleep apnea, especially in individuals with risk factors like obesity or lung disease. Report symptoms such as loud snoring or daytime fatigue to your healthcare provider.

• High Calcium Levels: Be cautious if you have cancer and are at risk for hypercalcemia. Regular monitoring of calcium levels may be necessary.

• Mental Health: Depression and suicidal thoughts have been reported with Jatenzo use. Seek immediate medical help if you experience significant mood changes or suicidal thoughts.

Contraindications: Avoid using this medication if you have breast or prostate cancer, are pregnant, or if you have low testosterone levels without certain medical conditions. Consult your healthcare provider for more information.

If you experience an overdose, seek emergency medical assistance promptly. Always communicate openly with your healthcare provider about any concerns or unusual symptoms while using this medication.

When taking this medication, some common side effects that you might experience include nausea, headache, and changes in skin color such as oily skin or acne. Additionally, you may notice changes in sexual interest, hair loss, or mild issues like indigestion and diarrhea. These side effects are generally mild, but if they persist or worsen, it is advisable to consult your healthcare provider.

There are also more serious side effects that require immediate medical attention. These include mental health changes such as anxiety or depression, trouble sleeping or snoring, and signs of liver problems like persistent nausea, vomiting, or yellowing of the skin or eyes. Other severe symptoms to watch for include swelling of the hands, ankles, or feet, unusual tiredness, fast or irregular heartbeat, and difficulties with urination. Men may experience prolonged or painful erections lasting four or more hours, which is a medical emergency.

In rare cases, very serious side effects may occur, such as shortness of breath, chest pain, or symptoms indicating a heart attack or stroke, like sudden dizziness, fainting, severe headaches, or weakness on one side of the body. Blood clots in the legs or lungs can present as pain, swelling, or trouble breathing, while severe allergic reactions may manifest as rash, itching, swelling of the face, tongue, or throat, and difficulty breathing. If any of these occur, seek medical help immediately.

Although these side effects can be concerning, it's important to remember that many individuals using the medication do not experience serious complications. Always communicate with your healthcare provider about any side effects you encounter.