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The safety information for methyltestosterone (Methitest) outlines important warnings and precautions for its use. Please read the following carefully and discuss any concerns with your healthcare provider.

• Liver Damage: Methyltestosterone may lead to liver damage, particularly with prolonged or high-dose use, which can become severe and life-threatening. Symptoms such as abdominal pain, pale stools, dark urine, or yellowing of the skin or eyes should be reported to your doctor immediately. Discontinuation might be necessary, and yellowing may resolve after stopping the medication. Risk is heightened with high-dose or long-term use.

• Risk of Blood Clots: This medication can increase the likelihood of blood clots, potentially leading to heart attacks or strokes. Seek immediate medical attention if you experience sudden shortness of breath, leg pain, swelling, warmth, or redness.

• Misuse and Addiction: Methyltestosterone is a controlled substance due to its potential for misuse, dependency, and addiction, especially when taken in doses higher than prescribed or combined with other testosterone products. The risk increases with higher doses and combination use.

• Edema (Fluid Retention): Methyltestosterone may cause swelling in the limbs due to fluid retention, which can be dangerous for individuals with heart, kidney, or liver issues, potentially leading to heart failure. Contact your healthcare provider if you notice swelling or have difficulty breathing. Discontinuation and diuretics may be necessary. The risk is elevated in those with pre-existing heart, liver, or kidney conditions or when taking other medications that cause swelling.

• Hypercalcemia (High Calcium Levels): In patients with breast cancer, methyltestosterone may increase calcium levels in the blood, potentially causing nausea, vomiting, weakness, or confusion. Notify your oncologist if these symptoms occur, as the medication may need to be stopped. The risk is specific to individuals with breast cancer.

• Bone Maturation in Children: In children, methyltestosterone can accelerate bone maturation without a corresponding increase in height, potentially resulting in a shorter adult stature. The risk is greater in younger children. Discuss any concerns with your child's healthcare provider.

Contraindications:

• Males with breast or prostate cancer should not use methyltestosterone.
• Females who are pregnant or could become pregnant should avoid this medication due to potential harm.

Always consult your healthcare professional before starting methyltestosterone if any of these warnings or contraindications apply to you.

When using this medication, some people may experience common side effects that are generally mild. These can include nausea, vomiting, headache, changes in skin color, increased or decreased sexual interest, oily skin, hair loss, acne, and breast enlargement. If any of these persist or worsen, it is advisable to consult a healthcare professional for guidance.

There are also other side effects that, while not as common, have been reported. These include a deeper voice, irregular or missed menstrual periods, increased facial and body hair, and changes in sex drive. If these symptoms occur, especially if they become severe, it is important to discuss them with a healthcare provider.

In some cases, serious side effects may occur, though they are rare. These require immediate medical attention and include symptoms such as mental or mood changes (including anxiety and depression), trouble sleeping, signs of liver disease, swelling in the hands, ankles, or feet, unusual tiredness, changes in heartbeat, and high blood pressure. Males may experience trouble urinating, breast swelling or tenderness, and prolonged or frequent erections, which can be serious if lasting four or more hours. Females may notice voice deepening, hoarseness, unusual hair growth, enlarged clitoris, and irregular periods.

Severe allergic reactions are also rare but necessitate prompt medical intervention. Symptoms might include rash, itching or swelling, severe dizziness, and trouble breathing. While this is not an exhaustive list of side effects, it is crucial to seek medical advice if any other unusual symptoms arise.