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This document provides essential safety and warning information for users of testosterone gel. It is crucial to follow all instructions and consult your healthcare provider with any concerns.

• Risk of Transfer and Early Puberty: Testosterone gel can be transferred to others through skin contact, potentially causing early puberty in children or male feature development in females. To minimize this risk, avoid contact with unwashed or unclothed areas where the gel has been applied. If you notice unexpected signs of puberty in children, such as an increase in genital size or aggressive behavior, contact your healthcare provider immediately.

• Increased Red Blood Cell Count and Blood Clots: The use of testosterone gel can increase your red blood cell count, leading to a risk of blood clots. Regular blood tests may be required to monitor your levels.

• Cardiovascular Risks: Testosterone gel may increase the risk of heart attack, stroke, or sudden cardiac death. Seek emergency assistance if you experience symptoms such as chest pain, difficulty breathing, or weakness on one side of the body.

• Potential for Misuse and Dependency: This medication is a controlled substance due to risks of misuse, dependency, and addiction. Misuse can lead to severe health issues, including heart problems and mental health disturbances.

• Prostate Health: Those with an enlarged prostate should be aware that testosterone gel can worsen symptoms. Report any changes in urination patterns to your healthcare provider.

• Liver Health: While testosterone gel is not known to cause liver damage, it's important to monitor for symptoms such as stomach pain and jaundice, especially if using other forms of testosterone.

• Swelling (Edema): The gel can cause fluid retention, leading to swelling in the arms and legs. This effect can be more severe if you have heart, liver, or kidney conditions, or are taking medications like corticosteroids.

• Sleep Apnea: Testosterone gel may worsen sleep apnea symptoms, especially in individuals with obesity or lung disease. Increased daytime sleepiness or observed pauses in breathing should be discussed with a healthcare provider.

• Hypercalcemia: The medication may cause elevated calcium levels in the blood, particularly in cancer patients. Regular blood tests may be necessary to monitor calcium levels.

Contraindications:

• Do not use testosterone gel if you have breast or prostate cancer.
• Women who are pregnant or breastfeeding should avoid this medication due to potential health risks.

Always follow your healthcare provider's guidance and report any unusual symptoms or concerns promptly.

This medication can cause a range of side effects, most of which are mild and manageable. Commonly experienced side effects include nausea, vomiting, headaches, dizziness, acne, hair loss, trouble sleeping, changes in sexual desire, redness or swelling of the skin, and skin color changes. Skin irritation, rashes, itchiness, and a high red blood cell count may also occur. While these symptoms often do not require medical attention, consult your healthcare provider if they persist or worsen.

More serious side effects, though less common, require prompt medical attention. These include breast pain or enlargement, swelling of the feet or ankles, weight gain, difficulty breathing, weakness, trouble urinating, increased urination, and changes in mood such as depression or anxiety. Additionally, some may experience changes in appetite, abnormal dreams, muscle weakness, and changes in smell or taste.

Rare but very serious side effects demand immediate medical care. Watch for signs of heart attack, such as chest pain and difficulty breathing, or stroke symptoms like facial drooping and weakness on one side of the body. Blood clots may present as leg pain or swelling, while liver damage may manifest as stomach pain, yellowing of the skin or eyes, and dark urine. In rare instances, a prolonged erection lasting more than four hours can occur, necessitating urgent medical attention to prevent permanent damage.

For individuals with diabetes, this medication might lower blood sugar levels, leading to symptoms like shakiness and rapid pulse. Be vigilant and consult your doctor for any necessary adjustments to your diabetes treatment. Though a serious allergic reaction is unlikely, seek help immediately if you experience rash, severe dizziness, or trouble breathing. Always inform your healthcare provider of any other unexpected effects you encounter.