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This medication, containing estrogens and progestins, can pose significant health risks, and it is important to weigh these risks and benefits with your healthcare provider. Below are critical safety warnings and precautions to consider if you are using or considering using this medication:

• Cardiovascular Risks: Use of estrogen and progestin therapies, such as Femhrt (ethinyl estradiol / norethindrone), may increase the risk of blood clots, heart attacks, and strokes. These therapies should not be used to prevent heart disease. Individuals with a personal or family history of blood clots, high blood pressure, diabetes, high cholesterol, obesity, or those who use tobacco are at higher risk.

• Breast Cancer: There is an increased risk of breast cancer associated with estrogen/progestin therapies. Do not use these therapies if you have a current or past history of breast cancer. Regular breast examinations and mammograms are advised.

• Uterine or Endometrial Cancer: Estrogen therapy, particularly without a balancing progestin, can increase the risk of uterine cancer. This risk is higher with prolonged use and high doses.

• Dementia: Starting estrogen/progestin therapy after age 65 may increase the risk of dementia. It should not be used for dementia prevention.

• Ovarian Cancer: Use of hormone therapy for menopausal symptoms may raise the risk of ovarian cancer. Report any unusual symptoms to your doctor.

• Liver or Gallbladder Problems: Estrogen therapy can exacerbate gallbladder disease and may cause liver damage. Discontinue use if jaundice occurs.

• Calcium Level Changes: Estrogen therapy can alter blood calcium levels, especially in women with breast cancer or bone metastases. Monitor for symptoms such as muscle weakness or nausea.

• Vision Problems: Rare vision issues due to blood clots in the eyes may occur. Report any vision changes immediately.

• High Triglyceride Levels: Estrogen therapy may elevate triglycerides, potentially leading to pancreatitis. Regular blood tests are recommended.

• Thyroid Hormone Levels: Estrogens can impact thyroid hormone levels, requiring dose adjustments of thyroid medication.

• Fluid Retention: This medication may cause fluid retention, exacerbating conditions such as heart failure or kidney damage.

• Worsening of Conditions: Estrogen therapy can worsen conditions like asthma, diabetes, seizures, migraines, blood disorders, lupus, and liver problems. Discuss your medical history with your doctor.

Contraindications:

• Avoid this medication if you have undiagnosed vaginal bleeding, a history of breast or other estrogen-sensitive cancers, blood clots, heart attack, stroke, liver disease, blood-clotting disorders, or if you are pregnant.

Emergency Actions:

• In case of overdose, seek immediate medical attention.

It is crucial to use the lowest effective dose for the shortest possible duration and have regular consultations with your healthcare provider to determine the necessity of continued use. Regular physical exams are recommended for long-term users.

When taking this medication, some common side effects may occur, though they are usually mild. These include stomach upset, nausea, vomiting, bloating, breast tenderness or pain, headache, and weight changes. Swelling in any part of the body and stomach pain are also possible. If these symptoms persist or worsen, it is advisable to consult your healthcare provider for guidance and reassurance.

There are other side effects that might be experienced, such as changes in vaginal bleeding, vaginal yeast infection, breast enlargement, mood changes, trouble sleeping, rash, and itching. While these are generally not serious, you should contact your healthcare provider if they become bothersome.

On rare occasions, some side effects may be severe and require immediate medical attention. These include persistent nausea or vomiting, mental or mood changes like depression or memory loss, breast lumps, unusual vaginal bleeding, severe abdominal pain, yellowing of the eyes or skin, dark urine, and increased thirst or urination. Serious allergic reactions, though very rare, may present as a rash, swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing.

Additionally, this medication may rarely cause serious complications from blood clots, heart attack, or stroke. Symptoms like chest pain, shortness of breath, sudden severe headache, weakness on one side of the body, confusion, trouble speaking, sudden vision changes, or pain and swelling in the groin or calf should prompt immediate medical help. There is also a rare risk of uterine, ovarian, or breast cancer, signaled by unusual vaginal bleeding, pelvic pain, or breast lumps. Abnormal changes in calcium levels can manifest as tiredness, muscle weakness, spasms, or tingling sensations and should be addressed urgently. If any other effects not listed are noticed, contacting a healthcare provider is recommended.

Femhrt (ethinyl estradiol / norethindrone) can interact with several medications, and it's important to inform your doctor and pharmacist about any other drugs or supplements you're taking, whether they are prescribed, over-the-counter, vitamins, or herbal products.

Some medications should not be used with Femhrt. These include dasabuvir, ombitasvir, paritaprevir, ritonavir, and tranexamic acid. Using them together might require your doctor to either avoid prescribing Femhrt or alter your other medications.

There are other drugs that are usually not recommended with Femhrt, but might be necessary in certain situations. If prescribed together, your doctor may adjust the dosage or frequency of one or both medications. These include a wide range of medications such as amoxicillin, carbamazepine, dexamethasone, and many others listed.

Additionally, some medicines may increase the risk of side effects when used with Femhrt, but could still be the best treatment option for you. In such cases, your doctor may modify your treatment plan accordingly. This category includes drugs like amitriptyline, diazepam, and warfarin, among others.

This medication can also interfere with lab tests, such as the metyrapone test, potentially causing false results. Ensure that all healthcare providers and lab personnel are aware that you are taking Femhrt.