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Here is important safety and warning information regarding the use of Karbinal ER (carbinoxamine). It is crucial to carefully consider these warnings and consult your healthcare provider if you have any concerns or questions.

• Risk of Fatality in Young Children: Karbinal ER is not safe for children under 2 years old due to reports of fatalities. It is essential to store this medication safely out of reach of young children. Additionally, avoid breastfeeding while taking this medication, as it may pass into breast milk and harm infants. If a child under 2 ingests it, contact Poison Control immediately at 1-800-222-1222. Consider discussing alternative treatments with your pediatrician for children under this age.

• Drowsiness: This medication may cause drowsiness, impacting your alertness and reaction time. The sedative effect can be heightened in older adults, with alcohol consumption, or when combined with other sedative medications like opioids and benzodiazepines. Refrain from driving or operating machinery until you understand how Karbinal ER affects you. It's advisable to avoid alcohol during treatment. Discuss any potential drug interactions and management strategies with your healthcare provider.

• Exacerbation of Pre-existing Conditions: Inform your healthcare team of all existing medical conditions before starting Karbinal ER. As an antihistamine with anticholinergic properties, it might aggravate issues like glaucoma, hyperthyroidism, heart disease, high blood pressure, stomach ulcers, urinary retention, and an enlarged prostate.

• Sulfite Allergy: Karbinal ER contains sulfites, which may trigger severe allergic reactions or asthma attacks. If you have a sulfite allergy or a history of asthma, inform your prescriber. Seek immediate medical attention if you experience breathing difficulties, wheezing, coughing, or chest tightness.

Contraindications

This medication should not be used under the following conditions, as it may pose significant health risks. Consult your healthcare provider if any apply:

• Children under the age of 2.
• Concurrent use of monoamine oxidase inhibitors (MAOIs) such as phenelzine, tranylcypromine, and selegiline.

When taking this medication, you may experience common side effects such as drowsiness, dizziness, headaches, blurred vision, stomach discomfort, or dry mouth, nose, and throat. These symptoms often improve as your body adjusts to the medication. To alleviate dry mouth, try sipping water, chewing sugarless gum, or using a saliva substitute. To prevent dizziness, rise slowly from sitting or lying positions. It's important to drink plenty of fluids to prevent mucus thickening in the lungs, unless otherwise advised by your healthcare provider.

In some instances, individuals may encounter less common side effects, including trouble with coordination, skin sensitivity to light, chills, low blood pressure, tiredness, nausea, vomiting, or trouble sleeping. These are generally mild, but if they persist or worsen, it's advisable to consult your healthcare provider.

Serious side effects, though rare, require immediate medical attention. These include mental or mood changes such as hallucinations or confusion, ringing in the ears, difficulty urinating, easy bruising or bleeding, fast or irregular heartbeat, or seizures. Additionally, be alert for signs of a serious allergic reaction, such as rash, itching, severe dizziness, or trouble breathing. If you experience any of these symptoms, seek urgent medical care.

Karbinal ER (carbinoxamine) has the potential to interact with various medications. It is crucial to inform your doctor and pharmacist about all medications and supplements you are taking, including prescribed, over-the-counter, vitamins, and herbal supplements.

Some products, such as skin-applied antihistamines like diphenhydramine cream or ointment, can interact with this medication. Additionally, if you are using drugs that cause drowsiness, such as opioid pain or cough medications (e.g., codeine, hydrocodone), alcohol, cannabis, sleep aids, or anxiety medications (e.g., alprazolam, lorazepam, zolpidem), muscle relaxants (e.g., carisoprodol, cyclobenzaprine), or other antihistamines (e.g., cetirizine, diphenhydramine), it is important to notify your healthcare provider.

This medication may also interfere with certain lab tests, such as allergy skin tests, possibly leading to inaccurate results. Ensure that all your healthcare providers and lab personnel are aware that you are using this medication.

There are some medications that should not be used with Karbinal ER due to potential interactions. These include Calcium Oxybate, Furazolidone, Iproniazid, Isocarboxazid, Linezolid, Magnesium Oxybate, Methylene Blue, Moclobemide, Pargyline, Phenelzine, Potassium Oxybate, Procarbazine, Rasagiline, Selegiline, Sodium Oxybate, and Tranylcypromine. Your doctor may decide against using Karbinal ER if you are taking any of these.

Other medications, such as Alfentanil, Alprazolam, Amifampridine, and many others, may require special consideration. If prescribed together, your doctor might adjust the dose or frequency of one or both medications.

Always check the labels on all your medications for ingredients that may cause drowsiness and consult your pharmacist to ensure safe use.