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Krazati (adagrasib) is associated with several potential risks and it is essential to be aware of these while undergoing treatment. Below are important safety warnings and precautions to consider:

• Digestive System Issues: Krazati (adagrasib) frequently causes digestive side effects such as nausea, vomiting, or diarrhea, especially within the initial weeks of treatment. While these are usually manageable with medication, in rare cases, severe issues like bleeding, blockages, or inflammation in the gut can occur, potentially becoming life-threatening. If you experience persistent stomach pain, severe nausea, or difficulty retaining food, contact your oncologist immediately. They may adjust your treatment or prescribe additional interventions.

• Heart Rhythm Concerns: This medication can alter heart rhythms, leading to QT interval prolongation, which can be serious. Risk factors include personal or family history of heart rhythm abnormalities, low potassium or magnesium, and concurrent use of other QT-prolonging medications. Regular electrocardiograms (EKGs) and blood tests to monitor electrolyte levels will be necessary to ensure safe use.

• Liver Health: Krazati (adagrasib) has the potential to cause liver damage, which might not present symptoms initially. Routine blood tests to monitor liver function will be required before starting treatment and monthly for the first three months. Elevated liver enzymes may be detected, indicating possible liver injury, but these often normalize within a few weeks.

• Lung Damage: Although uncommon, lung damage can occur and may be severe. Symptoms typically appear about three months into treatment but can arise sooner or later. Report any new or worsening cough, shortness of breath, or fever to your oncologist promptly. Temporary discontinuation of the medication may be necessary to assess lung health.

It is crucial to maintain open communication with your healthcare provider throughout your treatment with Krazati (adagrasib) to manage these potential risks effectively.

When taking this medication, some individuals may experience common side effects such as diarrhea, nausea, fatigue, vomiting, and muscle or joint pain. These are generally mild but can become bothersome. It's helpful to manage these symptoms by eating small meals and adjusting activity levels. If symptoms persist or worsen, consulting with a healthcare provider is advised.

Serious side effects, although rare, require immediate medical attention. These include severe digestive issues like persistent stomach pain, black stools, or vomit resembling coffee grounds, which may indicate internal bleeding. Life-threatening heart problems may present as chest pain, shortness of breath, or an irregular heartbeat. Signs of liver damage include persistent nausea, yellowing of the skin or eyes, and dark urine. Additionally, this medication can cause severe lung issues, presenting as a new or worsening cough, shortness of breath, or fever.

Other effects to be aware of include dizziness, constipation, and swelling of hands or feet. If you notice symptoms like a rash, severe dizziness, or difficulty breathing, these may indicate an allergic reaction, which is rare but requires urgent care. Always report new or concerning symptoms to a healthcare professional to ensure your safety and well-being.