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Here are the essential safety and warning details regarding the use of Lumakras (sotorasib). It is crucial to understand these points and discuss any questions or concerns with your healthcare provider.

• Liver Injury: Lumakras may potentially harm your liver. To mitigate this risk, regular blood tests are necessary to monitor liver function. These tests are typically conducted before initiating treatment, every three weeks at the beginning of the treatment, and then at reduced frequency. Liver damage has been reported within the first two months of treatment. Be vigilant for symptoms such as right-sided abdominal pain, yellowing of the skin or eyes, or dark urine. If liver damage is suspected, your healthcare provider may pause your treatment until liver function stabilizes, possibly resuming at a lower dosage.

• Lung Damage: Though uncommon, Lumakras can lead to severe lung issues, including life-threatening conditions. Such problems have been observed within the first four months of treatment. Report any new or worsening cough, breathing difficulties, or fevers to your healthcare provider immediately. Medication may need to be discontinued while lung function is assessed.

No explicit contraindications have been identified for Lumakras; however, always consult your healthcare provider for personalized advice based on your health status and history.

When taking this medication, some common side effects may include diarrhea, muscle or bone pain, fatigue, nausea, and cough. These are generally mild, but if they persist or worsen, contact your healthcare provider for advice. Other potential side effects may include vomiting, constipation, stomach pain, shortness of breath, or swelling. While these are less common, it's important to monitor any changes and consult your healthcare provider if you experience them.

There are also rare but serious side effects that require immediate medical attention. Signs of liver injury, such as right-sided stomach pain, yellowing of the eyes or skin, or dark urine, should be addressed urgently. Similarly, lung damage, indicated by symptoms like cough, shortness of breath, or fever, is a critical concern. Allergic reactions, though very rare, may present as a rash, itching, swelling, severe dizziness, or trouble breathing, and necessitate prompt medical attention.

Rashes are a common occurrence and often not serious, but it's crucial to seek medical help if you develop one, as it could signal a severe reaction. Always stay vigilant and report any unexplained or severe side effects to your healthcare provider for further guidance.

Sotorasib can be affected by other medications, altering its effectiveness. Drugs such as rifamycins (e.g., rifabutin) and certain seizure medications (e.g., carbamazepine, phenytoin) can influence how sotorasib is processed in your body. Additionally, sotorasib may accelerate the elimination of some medications, impacting their effectiveness. Examples include daridorexant, elacestrant, lonafarnib, mavacamten, quizartinib, and revumenib.

Furthermore, sotorasib may reduce the efficiency of hormonal birth control methods like pills, patches, or rings, potentially leading to unintended pregnancy. It's important to consult with your healthcare provider about using additional reliable birth control methods while taking this medication. If you experience unusual spotting or breakthrough bleeding, contact your doctor, as these could indicate reduced birth control effectiveness.