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Here is important safety and warning information regarding the use of levalbuterol (Xopenex HFA). Please review these details carefully and discuss any concerns with your healthcare provider.

• Breathing Issues: In rare cases, levalbuterol (Xopenex HFA) can lead to bronchospasm, causing breathing difficulties, wheezing, coughing, and chest discomfort. If you experience trouble breathing immediately after using this medication, seek medical attention promptly.

• Cardiovascular Concerns: Although unlikely with recommended doses, levalbuterol (Xopenex HFA) may affect blood pressure, heart rate, and heart rhythm. Those with high blood pressure or existing heart conditions should monitor their blood pressure and heart rate regularly. Avoid exceeding the prescribed dosage and inform your healthcare provider if you notice dizziness, fatigue, tremors, rapid heartbeat, or weakness.

• Allergic Reactions: Levalbuterol (Xopenex HFA) can cause allergic reactions, including severe responses such as facial swelling, shock, and anaphylaxis. If you experience hives, skin rash, swelling of lips or tongue, or difficulty breathing, seek immediate medical assistance.

• Low Blood Potassium: Overuse of levalbuterol (Xopenex HFA) may result in low potassium levels, leading to symptoms such as fatigue, muscle cramps, a racing heart, and tingling sensations in the extremities. Typically, potassium levels normalize over time, but consult your provider if you require frequent use of the medication.

Contraindications:

• Avoid using levalbuterol (Xopenex HFA) if you have a known allergy to levalbuterol or albuterol, as it could pose serious health risks. Always consult with your healthcare provider if you suspect any contraindications apply to you.

Common side effects:

• Nervousness
• Dizziness
• Shaking
• Trouble sleeping
• Headache
• Nausea
• Dry mouth
• Cough
• Sore throat
• Runny nose
• Asthma
• Body pain
• Vomiting
• Bronchitis

Serious side effects:

• Fast or pounding heartbeat
• Chest pain
• Irregular heartbeat
• Rapid breathing
• Confusion
• Paradoxical bronchospasm
• Allergic reaction (rash, itching, swelling, severe dizziness, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Albuterol

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Acebutolol
• Atenolol
• Bisoprolol
• Carvedilol
• Metoprolol
• Nadolol
• Propranolol
• Sotalol
• Amitriptyline
• Clomipramine
• Nortriptyline
• Epinephrine
• Methacholine